Rakhi Gibbons
Asst. Director, Life Sciences (520) 626-6695New technologies delivered to your inbox Subscribe
Compositions and Treatments for Haemophilus Influenzae
ua18-091 – Title: Compositions and Treatments for Haemophilus Influenzae Invention: This invention involves the generation, manipulation and administration of a non-toxic, broadly cross-reactive immunoprotective nontypeable H. influenzae vaccine. Background: H. Influenzae (Hi) is a Gram-negative anaerobic pathogenic bacterium responsible for causing otitis media (inner ear inflammation) in... Read More
A Method to Treat Post-Operative Atrial Fibrillation in Patients Undergoing Cardiac Bypass Surgery
ua17-252 – A Method to treat post-operative atrial fibrillation in patients undergoing cardiac bypass surgery
Concurrent Injection of Biomaterial Improves Efficacy of TMR Therapy
ua18-086 – Title: Concurrent Injection of Biomaterial Improves Efficacy of TMR Therapy Invention: This invention uses an extracellular matrix derived from the amniotic membrane that is injected with stem cells to increase vascularization of heart scar tissue after surgery with transmyocardial revascularization therapy. Background: Advanced heart failure continues to be a prevalent cause of... Read More
Libra: Comparative Metagenomics With MapReduce
ua18-111 – Title: Libra: Comparative Metagenomics with MapReduce Invention: Libra is an algorithm for all-vs-all genome sequencing tool to identify problematic microbes. It handles large data sets with speed, accuracy and efficiency. Background: Most bioinformatics methods need a reference source of known genomes to ensure accurate measurements of depth and variance. Sequencing and comparing... Read More
“Digital Reflexes”: Quantitation and Signatures of Superficial Reflexes via Stretchable Electronic Wearable Sensors
ua18-128 – Title: “Digital Reflexes”: Quantification and Signatures of Superficial Reflexes via Stretchable Electronic Wearable Sensors Invention: This invention provides a method of deep tendon reflex assessment via stretchable electronic sensors containing tri-axial accelerometers and EMG signal detection, which allows for quantitation of motion and EMG “signatures” of a specified reflex. ... Read More
Drug Metabolite as a Non-Invasive Biomarker for Nonalcoholic Steatohepatitis (Nash)
ua18-113 – Title: Drug Metabolite as a Non-Invasive Biomarker for Nonalcoholic Steatohepatitis (NASH) Invention: This invention is a novel approach to diagnosing patients with Non-Alcoholic Steahepatitis (NASH). Typically NASH is diagnosed through invasive liver biopsies. This technology evades the traditional risks associated with liver biopsies in favor of a diagnosis that incorporates a pill and... Read More
PAR 2 Inhibitors
ua18-135 – Title: PAR 2 Inhibitors Invention: This invention describes new inhibitors of the protease activated receptor 2 (PAR2), a G protein coupled receptor (GPCR) involved in inflammatory related diseases, for the treatment of asthma and a wide range of other diseases. Background: It is estimated that by 2025 400 million people will be suffering from asthma. While the prevalence of asthma... Read More
Method for Treating Cftr-Mediated Chronic Sinusitis
ua18-193 – Title: Method for Treating CFTR-Mediated Chronic Sinusitis Invention: This technology is a drug-based therapeutic for chronic sinusitis (CS) in patients where the disease is caused by a single mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Background: Chronic sinusitis currently affects nearly 30 million Americans, with treatments including... Read More
Biomarker Signatures of Platelet Activation
ua18-230 – Title: Biomarker Signatures of Platelet Activation Invention: This invention is a mechanical biomarker signature of shear effects on cells for the purpose of detecting thrombosis early so it can be treated or intercepted prior to a thrombotic event. Background: Thrombosis is a pathophysiological event that can trigger conditions like stroke or heart attack. The efficacy of many... Read More
Method for Identifying Novel Peptide and Peptidomimetic Agonists and Antagonists to Protease-Activated Receptors
ua12-040 – Background: Protease-Activated Receptors (PARs) include four proteins (PAR1, PAR2, PAR3, and PAR4), and together are a subfamily of G-protein coupled receptors. Endogenous proteases are known to contribute to a number of pathological processes via direct activation of PARs. For example, PAR2 in particular is known to play a role in pathologies associated with the release of proteases.... Read More
Sponge & Bloom: Dual Purpose Kitchen Aid
ua17-207 – Title: Sponge & Bloom: Dual Purpose Kitchen Aid Invention: This invention is a sponge holder that is designed to eliminate the use of sponge trays and holders by placing a sponge holder atop a small potted plant. After use, the user simply places the sponge in the holder where excess water runs off while the sponge dries, which helps water the plant. Background: Traditional sponge... Read More
Acoustic Detection of Activated Ultrasound Phase-Change Contrast Agents
ua18-143 – Title: Acoustic Detection of Activated Ultrasound Phase-Change Contrast Agents Invention: This technology is a new technique to detect the acoustic waves emitted when a phase change contrast agent (PCCA) changes from a liquid to a gaseous state. It allows for the real-time monitoring of PCCAs, quantification of activation, and spatial localization. Currently, there are no other available... Read More
Nox4 Small Molecule Inhibitors for the Treatment of Fibrotic Disorders.
ua16-067 – Title: Nox4 Small Molecule Inhibitors for the Treatment of Fibrotic Disorders Invention: This technology identifies a series of small molecule inhibitors of NOX4 for the treatment of idiopathic pulmonary fibrosis (IPF) and other fibrotic disorders. In particular, it provides methods, screening assays, and related absorption, distribution, metabolism, excretion (ADME) studies for the... Read More
Enteral Electrical Constructs
ua17-051 – Title: Enteral Electrical Constructs Invention: This invention is a diagnostic and therapeutic system that is composed of ingestible, edible, and nutritive electric/electronic constructs in order to measure various aspects of the entire digestive system. Background: Electronic systems are vital in medical diagnostics and therapeutics, but current electronic systems are based largely... Read More
tPTX Device for Modified Veress Needle Assembly
ua16-121 – Title: Veress Needle Interface for Tension Pneumothorax Decompression Invention: Inventors at the University of Arizona have designed an interface for the modified Veress needle (mVN) to address the shortcomings of older devices used to treat tension pneumothorax such as traditional needle thoracostomy (NT). This interface serves as an attachment that adds additional functionality to the... Read More
Apelin Regulates Blood Vessel Growth
ua03-046 – Title: Apelin Regulates Blood Vessel Growth Basis of Invention. University of Arizona researchers have discovered a peptide, apelin, which is expressed in developing blood vessels, and positively regulates blood vessel growth. Manipulation of the levels of this peptide is expected to have implications in a range of clinical applications: increasing apelin levels may help patients with... Read More
Pharmacogenomics of Intergenic SNPs and in Silico Modeling for Precision Therapy
ua16-224 – Title: Pharmacogenics of Intergenic SNPs and in Silico Modeling for Precision Therapy Invention: A method for analyzing a single patient’s DNA and modeling how mutations and variations in intra-cell genomics will be expressed in the body. The information may be used to develop highly personalized therapies without the need for huge experimental data sets. Background: Personalized... Read More
Method, Device and System for Appendage Protection Therapy (Smart Offloading Boot)
ua15-080 – Smart Insole Introduction: Diabetic foot ulcers require a lot of monitoring for the wound healing process. Patients are asked to perform self-evaluations in between physician visits in order to keep an eye on high risk factors during the healing process. If high risk factors are found patients must then get into the doctor for treatment. This process leaves a lot of room for complications... Read More
Health Buddy
ua15-187 – Title: Mobile Platform for Tracking and Understanding Health Invention: Inventors at the University of Arizona have developed a mobile platform designed to help patients improve the understanding of their health data, as well as communicate more effectively with medical professionals. Envisioned as an application that improves the efficiency of the relationship between patients and... Read More
Systems, Methods, Devices and Materiel for Definition, Monitoring and Modulation of Organism Strength
ua16-024 – Title: Health Behavior Change Training Program (Reach) Invention: An in-person workshop and website that provides information and training for “helpers” and/or complementary and alternative medicine (CAM) practitioners aid individuals in changing harmful health behaviors, including tobacco cessation. The training, associated with CAM, focuses on “helping conversations” that avoid... Read More
Systems, Methods, Devices and Materiel for Definition, Monitoring and Modulation of Organism Flexibility
ua16-025 – Title: Health Behavior Change Training Program (Reach) Invention: An in-person workshop and website that provides information and training for “helpers” and/or complementary and alternative medicine (CAM) practitioners aid individuals in changing harmful health behaviors, including tobacco cessation. The training, associated with CAM, focuses on “helping conversations” that avoid... Read More
Methods, Systems and Devices for Codification, Analysis and Monitoring of Motion or Motion Description and Analysis System
ua16-241 – Title: Methods, Systems and Devices for Codification, Analysis and Monitoring and Motion or Motion Description and Analysis System Invention: The technology consists of wearable, thin, stretchable electronic systems. These wearable trackers have accelerometers and gyroscopes to capture coordinates, dimension, velocity, and acceleration data. Background: In order for a motion tracking... Read More
Point of Care Microfluidic Aggrogometer
ua17-170 – Title: Point of Care Microfluidic Aggrogometer Invention: The invention is a device to assess platelet aggregation for diagnosis of thrombotic diseases and continual monitoring with anti-platelet therapy. Background: Heart disease is the leading cause of death in the United States and, with over 50% of those deaths due to clot formation from myocardial ischemia and infarction.... Read More
Compositions and Methods for Detecting Complicated Sarcoidosis
ua17-208 – Title: Compositions and Methods for Detecting Complicated Sarcoidosis Invention: The invention is a novel biomarker capable of identifying complicated sarcoidosis, as well as patients at risk for increased morbidity due to sarcoidosis. Background: Sarcoidosis is an inflammatory disease involving abnormal collections of cells that form lumps and typically begins in the lungs. Genetic... Read More
Targeting Extracellular NAMPT and TLR4 as a Therapy for Pulmonary Arterial Hypertension
ua17-159 – Title: Targeting Extracellular NAMPT and TLR4 as a Therapy for Pulmonary Arterial Hypertension Invention: The invention is the targeting of nicotinamide phosphoribosyltransferase (NAMPT) for the treatment of pulmonary arterial hypertension. Background: Pulmonary arterial hypertension is a progressive disease that leads to increased resistance and eventual right ventricular failure and... Read More
A Diagnostic Test for Schizophrenia
ua16-066 – Title: A Diagnostic Test for Schizophrenia Invention: A method by which schizophrenia can be diagnosed by providing patients with a single dose of antipsychotic medication and a questionnaire. The questionnaire serves to determine their degree of sleepiness/sedation in response to the medicine, which aids in dictating their diagnosis. In addition, a blood test for serotonin 2A receptors,... Read More
Convenient 18F Radiolabeling of Biomolecular Agents
ua17-111 – Title: Convenient 18F Radiolabeling of Biomolecular Agents Invention: A chemical synthesis method that utilizes a radioactive version of the Fluorine atom (18F) in order to conveniently and rapidly label biomolecules and other small molecules. Background: A Positron Emission Tomography (PET) scan helps reveal how tissues or organs are functioning, specifically to detect certain... Read More
Interface
ua16-061 – Title: Sensor Interface for Preventing Tissue Damage Invention: Inventors at the University of Arizona have developed a sensor interface designed to detect and prevent tissue damage. The device is attached to the subject’s skin, senses and identifies regions within the skin-contact surface at risk for damage from these stressors, and then makes adjustments to those regions in order to... Read More
Systems and Signatures for Cardiopulmonary Resuscitation
ua17-136 – Title: Systems and Signatures for Cardiopulmonary Resuscitation Invention: The invention is a system and method to quantify optimal CPR through the Bio-Stamp. This system will monitor and provide feedback to the CPR provider if CPR is being performed correctly, allowing the CPR provider to make corrections and standardizing the way to individuals are trained in CPR. Background:... Read More
Image Guided Surgery for Pancreatic Cancer
ua14-174 – Title: Image Guided Surgery for Pancreatic Cancer Invention: The technology is the combination of targeted microbubbles to cancer cells and a novel imaging device to accurately and rapidly assess the surgical margin for presence of unseen cancer in the operating room. The device is a portable combined multi-photon imaging (MPI) and optical coherence tomography (OCT) imaging device to... Read More
Protease-Activated Receptor Type 2 Modulators and Inhibitors
ua14-181 – Invention: UA14-181 is a novel and highly potent PAR modulator. Because PAR activation plays a pivotal role in a variety of inflammatory diseases, high affinity and potent ligands of the PAR receptor like those found in UA14-181 represent a novel approach to the prevention and treatment of inflammatory diseases. Background: PAR is a well-known cell surface receptor that is involved in the... Read More
PAR3 Inhibitors as Therapeutic for Pain
ua16-176 – Title: PAR3 Inhibitors as Therapeutic for Pain Invention: The technology identifies protease activated receptor-3 (PAR3) and PAR3 inhibitors as a novel target for the treatment of pain. Background: Pain is one of the most common reasons in which individuals seek medical attention. Globally, pain affects at least 1.5 billion people, with the incidence rate increasing complementary to... Read More
Metabolomic Biomarker of Altered Hepatic Function
ua08-019 – Title: Metabolomic Biomarker of Altered Hepatic Function Invention: We have developed a metabolomic biomarker that clearly delineates patients with steatosis that have a normal metabolism rate from patients with steatohepatitis and the resulting decreased capacity to metabolize and eliminate drugs. We are in the process of determining whether the test can be conducted simply with urine... Read More
Sweat Biomarkers as an Indication of Physiological Conditions
ua14-146 – Title: Sweat Biomarkers as an Indication of Physiological and Psychological Conditions Invention: Inventors at the University of Arizona have devised a means by which cortisol isomer ratios in human sweat can be measured and used to evaluate the physiological or psychological state of the patient. Certain cortisol isomer ratios are associated with particular conditions or disorders (high... Read More
Precise, Accurate Bacterial Identification System
ua14-034 – Title: BugSeq - Bacterial Identification in Clinical Infections Invention: The technology is a rapid, whole genome sequence analysis tool to determine the type of bacteria, resistance, and virulence that lacks biases introduced by culture-based methods. Background: The lack of accurate and precise methods to identify bacteria forces clinicians to use broad based antibiotic regimens.... Read More
Novel Target for the Treatment of Glaucoma
ua11-125 – Title: Control of Intraocular Pressure by Modification of Soluable Adenylate Cyclase Activity Invention: The technology is the manipulation of anterior chamber drainage in the eye by targeting unique pathways. Bicarbonate sensitive soluble adenylyl cyclase regulates the secretion of substances into the aqueous humor and resulting pressure. Deficiency in bicarbonate channel bestrophin-2... Read More
Prostate Cancer Patient Blood Sample Collection and PSA Survey
ua10-061 – Blood samples collected from participants in the NIH-funded Watchful Waiting Study, a study of selenium supplementation in men with prostate cancer. Samples were processed to prepare plasma and tested for Prostate Specific Antigen (PSA) level. Samples are available for licensing.
Smart Textile to Predict Diabetic Foot Ulcer
ua15-161 – Title: Smart Textile to Predict Diabetic Foot Ulcer Invention: The invention is a movable, washable smart textile that can measure abnormalities in pressure and temperature when a patient applies pressure while walking on it. The textile can analyze the data and send alerts to the patient when abnormalities suggest the presence of diabetic foot ulcers (DFU) and/or the likelihood of falls... Read More
Brief Health Behavior Change Intervention Training Program for Health Professionals
ua14-025 – Title: Health Behavior Change Training Program (Reach) Invention: An in-person workshop and website that provides information and training for “helpers” and complementary and alternative medicine (CAM) practitioners to better help individuals to change harmful health behaviors, including tobacco cessation. Training focuses on “helping conversations” that avoid confrontation and emphasize... Read More
Brief Tobacco Cessation Intervention Training Program for "Health Influencers"
ua14-024 – Title: Health Behavior Change Training Program (Reach) Invention: An in-person workshop and website that provides information and training for “helpers” and complementary and alternative medicine (CAM) practitioners to better help individuals to change harmful health behaviors, including tobacco cessation. Training focuses on “helping conversations” that avoid confrontation and emphasize... Read More
Method for Determining Cell Stiffness
ua15-179 – Title: Method for Determining Cell Stiffness Invention: The present invention is a minimal-contact method used to trap and measure the stiffness of platelets in relation to the whole cell. Background: Platelets, essential for hemostasis, are easily activated via biochemical and mechanical stimuli. In addition, cell stiffness is a vital parameter modulating the mechano-transduction of... Read More
Real-Time Reflex Pupillometry Device for Neuro-Physiologic Monitoring
ua15-141 – This device provides for a solid state camera system and light source onto an extraocular lens for real-time monitoring of cranial nerve pathways on anesthetized patients. Intraoperative neurophysiologic monitoring provides the surgical team real-time feedback during surgeries that involve the brain, spinal cord, or peripheral nervous system. This allows for prompt interventions... Read More
Treatment for Type II Diabetes
ua16-043 – Title: Biomarkers of metformin efficacy and methods related to Type II diabetes Invention: The present invention provides methods, compositions, and related uses for the interaction between metformin and methylglyoxal. In addition, this invention provides methods for detecting the efficacy of metformin therapy while exploring the metformin-MG reaction, unequivocally determining the... Read More
Virtual Reality Systems and Methods for Improving Clinical Outcomes
ua16-018 – Title: Virtual Reality Treatment System Invention: The invention provides a virtual reality (VR) experience, including VR goggles and haptic feedback devices, for patients to explain the benefits of a medical treatment or the consequences of non-compliance. The immersive experience seeks to have a greater impact on a patient’s behavior versus a discussion with a healthcare provider alone.... Read More
Smart Insole
ua15-079 – Technology ID: UA15-079 Technology Background: Diabetic foot ulcers impact nearly 1 in 4 patients with diabetes. Over 50% of those who do develop foot ulcers requiring hospitalization at some point in their lives. Once infection sets in, amputation may be the only option for the patient’s survival. Approximately 1 in 5 foot ulcers will require amputation, and over 80% of lower limb,... Read More
Novel microRNA Gene Expression Profiling for Sarcoidosis Diagnosis
ua15-193 – Title: Novel microRNA gene expression profiling for sarcoidosis diagnosis Invention: The invention is a microRNA (miRNA) regulated gene signature that can detect sarcoidosis in patients. The invention consists of 46 miRNAs and 1,559 genes that were differentially expressed with sarcoidosis severity. In addition, 17 genes were identified to form a diagnostic scale. A high score on the... Read More
Reactive Oxygen Species Gene Signature Predicts Survival in Sepsis
ua16-068 – Title: Reactive oxygen species gene signature predicts survival in sepsis Invention: The technology is a 21-gene reactive oxygen species (ROS)-associated molecular signature that predicts survival in septic patients. Background: Sepsis syndrome’s mortality rate is 26% to 82% depending on whether septic shock occurs. Currently there are no reliable diagnostic biomarkers available to... Read More
Diabetic Wound Healing Through Pharmacological Activation of NRF2.
ua16-108 – Title: Diabetic Wound Healing Through Pharmacological Activation of NRF2 Invention: The technology presented identifies a series of lead compounds amenable to pharmaceutical development of NRF2 activation to enhance diabetic wound healing. In particular, the present invention demonstrates the potential for wound healing with both systemic and/or topical administration of the disclosed... Read More
Phase Change Nanodroplet - Liposome Conjugates for Enhanced Drug Delivery
ua15-034 – Technology ID: UA15-034 Technology Background: Blood-brain barrier (BBB) technology is a set of scientific techniques and practices that enables medicinal substances to pass through the previously impenetrable BBB. BBB technology combines technologies from the pharmaceutical/biotechnology with advanced drug delivery technologies, allowing therapeutics to cross the blood-brain barrier. ... Read More
Biostable Segmented Elastomers and Engineering Thermoplastics
ua14-016 – A continuing need exists for biostable, tough elastomers, particularly for use in long-term, dynamic medical implants (including, but not limited to: cardiac pacing lead insulation, cardiac assist device bladders, chronic indwelling catheters, and other medical implants subject to biodegradation). Existing elastomers used in these applications (e.g. polydimethylsiloxanes and segmented... Read More