Inter-Objective Baffle SystemTechnology #ua02-011
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- Ronald Weinstein Department Head, Pathology
- Roland Shack Professor, Optical Sciences
- Peter Bartels Professor Emeritus, Optical Sciences
- Chen Liang Graduate Assistant, Optical Sciences
- Michael Descour Associate Professor, Optical Sciences
- Managed By
- Rakhi Gibbons Asst. Director, Life Sciences (520) 626-6695
Background: Previous to this invention, slides would be viewed through a light microscope or through electronic images captured through a digital imaging mode. Early microscopes with motorized stages also allowed slides to be moved one portion of the specimen at a time into the field of view of the microscope. By assembling these images, it was possible to obtain microscopic digital images of the entire specimen. Previous light microscopes had a single optical pathway which had a miniscule field of view less than that of a single slide (25mm by 75mm). In order to scan the entire slide would take multiple passes. This created the problem of both time spent and of image quality gained from having to break an image apart into these passes. Making the objective lens larger in a single array does not solve this problem, as this would result in a larger system which requires substantial stabilization during scanning and imaging.
Invention: This technology discloses a novel method of combating this problem, by using a multi-axis imaging system used to scan an entire specimen on a microscope slide in a single pass. It can be used by pathologists to analyze tissue samples, liquid specimens, and other medical specimens, with a variety of applications and outputs.
Application: The object of the present invention is to provide an imaging system which can rapidly scan a microscopy specimen, or other object, and produce an image of the entire specimen.
This invention has been demonstrated to be superior to the state-of-the-art in (a) theory, (b) simulations, and © using real data. Our simulation results show orders of magnitude in improvement, as compared to traditional methods. Real results from data closely replicate the performance of our simulations.
- protects each imaging element from cross talk and still allows illumination for the purposes of imaging;
- can be built to the same accuracy as lower cost lens;
- can be used to image an entire slide array in a single pass, without degrading image quality;
- method does NOT require a phase unwrapping routine.
Status: US Patent 7,116,437 issued on 10/03/2006
Lead Inventor: Dr. Peter Bartels
UA ID: UA02-011