Mouse Hybridoma Cell Line Producing IgG Monoclonal Antibody (2C4) Specific for Taura Syndrome Virus (Tsv) of Penaeid Shrimp

Technology #ua09-007

Questions about this technology? Ask a Technology Manager

Download Printable PDF

Isabelle Cote
Bonnie Poulos
Assistant Staff Scientist, Ecology & Evolutionary Biology
Donald Lightner
Professor, Veterinary Science & Microbiology
Managed By
Tod Mccauley


Researchers at the University of Arizona have developed MAb (2C4) that is a highly specific for the common shrimp disease caused by Taura Syndrome Virus (TSV); it could be used alone or in a “cocktail” with other antibodies to recognize several strains of TSV. At least five TSV genotypes have been identified and named to denote geographic origin of the type strain: TSV-HI (Hawaii), TSV- SI (Sinaloa), TSV-BZ (Belize), TSV-VE (Venezuela) and TSV-TH (Thailand).


Taura Syndrome Virus (TSV) is a major threat to the $11 billion global shrimp farming industry. TSV-resistant shrimp varieties have been developed, but viral variants have emerged that may pose new threats. University of Arizona monoclonal antibody 2C4 shows high specificity for three viral variants and, thus, could be important to developing economies where the export of shrimp provides much needed revenues. TSV is a single-stranded RNA virus. Due to the lack of fidelity during genome replication, mutation rates are higher in most RNA viruses than in DNA viruses.


  • Antibody 2C4 is highly specific for TSV
  • Antibody is very stable
  • Diagnostic kit may be used in the field with no toxic chemicals or special expertise.


  • Diagnostic kit for detection of TSV and three mutations: TSV-BZ, TSV-HI and TSV-SI


Professor Donald V. Lightner

Isabelle Cote


Tod McCauley

Licensing Manager, Tech Launch Arizona

Refer to technology # UA09-007