Mouse Hybridoma Cell Line Producing IgG Monoclonal Antibody (2C4) Specific for Taura Syndrome Virus (Tsv) of Penaeid Shrimp

Technology #ua09-007

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Categories
Researchers
Donald Lightner
Professor, Veterinary Science & Microbiology
Bonnie Poulos
Assistant Staff Scientist, Ecology & Evolutionary Biology
Isabelle Cote
Managed By
Tod McCauley
Sr. Licensing Manager (520) 626-7916

Invention

Researchers at the University of Arizona have developed MAb (2C4) that is a highly specific for the common shrimp disease caused by Taura Syndrome Virus (TSV); it could be used alone or in a “cocktail” with other antibodies to recognize several strains of TSV. At least five TSV genotypes have been identified and named to denote geographic origin of the type strain: TSV-HI (Hawaii), TSV- SI (Sinaloa), TSV-BZ (Belize), TSV-VE (Venezuela) and TSV-TH (Thailand).

Background

Taura Syndrome Virus (TSV) is a major threat to the $11 billion global shrimp farming industry. TSV-resistant shrimp varieties have been developed, but viral variants have emerged that may pose new threats. University of Arizona monoclonal antibody 2C4 shows high specificity for three viral variants and, thus, could be important to developing economies where the export of shrimp provides much needed revenues. TSV is a single-stranded RNA virus. Due to the lack of fidelity during genome replication, mutation rates are higher in most RNA viruses than in DNA viruses.

Advantages

  • Antibody 2C4 is highly specific for TSV
  • Antibody is very stable
  • Diagnostic kit may be used in the field with no toxic chemicals or special expertise.

Applications

  • Diagnostic kit for detection of TSV and three mutations: TSV-BZ, TSV-HI and TSV-SI

Inventors

Professor Donald V. Lightner

Isabelle Cote

Contact

Tod McCauley

Licensing Manager, Tech Launch Arizona

TodM@tla.arizona.edu

Refer to technology # UA09-007