Synergistic Vaccine to Reduce Campylobacter Jejuni in Chickens

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Researchers
Lynn Joens
Professor, Veterinary Science & Microbiology
Bibiana Law
Assistant Research Professor, Veterinary Science & Microbiology
Alexandra Armstrong
Assistant Research Scientist, Veterinary Science & Microbiology
Managed By
Tod McCauley
Sr. Licensing Manager (520) 626-7916

Synergistic Vaccine to Reduce Campylobacter jejuni in Chickens

Campylobacteriosis, associated with the handling and consumption of poultry, is the number two bacterial food-borne disease in the U.S. To date, there is no method or vaccine commercially available to reduce numbers of Campylobacter from poultry going to processing. With about 8.9 billion broilers sold annually in the U.S., a value of $21.5 billion, a Campylobacter vaccine could have significant effects. Some Campylobacter vaccines have been attempted, however the most promising results have been achieved using attenuated vectors to deliver antigens because it can stimulate an intestinal mucosal response in chickens. Faculty at the University of Arizona developed a vectored vaccine that demonstrates significant reduction of Campylobacter in chickens. The vector incorporates two virulence genes that express protective antigens at high levels, stimulating strong humoral and mucosal immune responses without tissue damage.

The inventors identified two virulence genes and demonstrated that these genes demonstrate significant reduction in colonization of chickens. Vaccination trials demonstrated a significant 1-4 log reduction of cecal content in vaccinated chicks. The identified genes are to be either used individually, as two or three way component vaccine, or combined in the same vector.

Applications

•    Comply with performance standards for Campylobacter in chickens

•    Reduce colonization of Campylobacter in chickens

•    Possible reduction of Campylobacter in cattle, swine, cats and dogs

Advantages

•    Vaccine delivers antigen to the intestinal mucosa, main source of Campylobacter in chickens

•    Vector is not detectable 6 days after vaccination, making it safe for chicks, caretakers and consumers

•    Vaccine is cost effective

Lead Inventor: Lynn A. Joens

UAID: UA12-121