New Class of Mosquitocide

Technology #ua13-107

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Categories
Researchers
Jon Njardarson
Professor, Chemistry & Biochemistry
Jun Isoe
Assistant Research Scientist, Chemistry & Biochemistry
Roger Miesfeld
Professor, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Invention

The new technology developed is a compound developed using thiopyran methodology that has a unique hit in mosquito assays. The novel compound, FL-II-185, is a new class of mosquito selective inhibitor of blood feeding female mosquitoes. The compound inhibits nutrient processing in mosquitoes and is lethal. Additionally, the screening method used to identify the compound FL-II-185 could be used to identify additional mosquito-selective inhibitors of blood meal metabolism.

Background

Numerous diseases are spread by mosquitoes. One example, Dengue virus, is a mosquito born virus that infects ~250 million humans per year. The spread of mosquito-borne diseases can be restricted by decreasing mosquito populations in areas of high pathogen transmission.

Advantages

  • Targets blood feeding female mosquitoes using biochemistry
  • Does not work by neurotoxicity
  • Safe for use in agricultural areas
  • Not lethal in other insects such as bees
  • Potential use in other arthropods which feed on human blood

Applications

  • Pharmacological applications, it will be sold as an individual pharmaceutical drug.
  • Perhaps a government or Ngo sponsored program to prevent mosquito breeding.
  • Agriculture as a secondary vector for mosquito-borne illness.
  • May be some application for this particular chemical in a formulation with other chemicals.

Inventor

Jon Njardarson

Licensing Manager:

John Geikler

JohnG@TLA.arizona.edu

(520)626-4605