Biostable Segmented Elastomers and Engineering Thermoplastics

Technology #ua14-016

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Categories
Researchers
Arthur Coury
Principal
Marvin Slepian
Professor, Medicine
Managed By
Rakhi Gibbons
Asst. Director, Life Sciences (520) 626-6695

Background:

A continuing need exists for biostable, tough elastomers, particularly for use in long-term, dynamic medical implants (including, but not limited to: cardiac pacing lead insulation, cardiac assist device bladders, chronic indwelling catheters, and other medical implants subject to biodegradation). Existing elastomers used in these applications (e.g. polydimethylsiloxanes and segmented polyurethanes) have various shortcoming, and no single existing elastomer has an ideal combination of toughness and other mechanical properties while also being biocompatible and biostable (i.e. resistant to oxidative and hydrolytic biodegradation).  

Invention:

This invention involves the creation of novel, segmented polysulfone compositions, which consist of both hard and soft segments. These polysulfone compositions demonstrate a high degree of toughness and other useful elastomeric properties are biocompatible, and resistant to biodegradation. Further, the ratios of “hard” to “soft” segments are adjustable, allowing for the creation of customized, application-specific compositions with tailored elastomeric and chemical properties.  

Applications:

The biocompatibility, biostability, and unique, application adjustable elastomeric properties of these compositions mean that they are particularly well-suited for use in medical devices, both topical and implantable, and especially those for long-term use. Further, the unique combination of chemical stability and desirable, application-dependent adjustable elastomeric properties of these compositions mean they are also well suited for use in a variety of engineering thermoplastics applications.  

Advantages:

The present invention is offers a unique combination of chemical stability (particularly biostability), toughness, and other desirable elastomeric properties. Further, the ratios of “soft” to “hard” segments may be altered, allowing the compositions of this invention to be tweaked to achieve a number of different chemical and elastomeric properties. Users may thus adjust the properties of these compositions for the particular requirements of their intended use.  

Lead Inventors:

Marvin J. Slepian, M.D.,

Arthur J. Coury, Ph.D.

Licensing Manager

Rahki Gibbons

RakhiG@TLA.arizona.edu

(520) 626-6695

 

UA14-016