Stabilized Black Lipid Membranes Prepared via Polymer Scaffolding

Technology #ua14-172

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Categories
Researchers
Craig Aspinwall
Professor, Chemistry
Leonard Bright
Graduate Assistant, Chemistry & Biochemistry
Steven Scott Saavedra
Professor, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Invention

This invention presents a new approach for stabilizing BLMs relying on inexpensive commercially available materials. Here, a method is employed that chemically modifies the lipid membrane to dramatically improve BLM stability.

 

Background

Black lipid membranes (BLMs), are synthetic membranes used to measure ion channel activity. Suspended Lipid Membranes, BLMs, provide a key technological platform for the incorporation of ion channels and other biological nanopores. These nanopore membranes play a key role in DNA sequencing, biochemical sensing and have potential applications in medical diagnostics, environmental and biological sensing and other arenas. Limitations of BLMs are the poor chemical, mechanical, temporal and environmental stability, which restricts utilization to specialized operations.

 

Applications

  • DNA Sequencing
  • Biochemical Sensing
  • Medical Diagnostics
  • Environmental Sensing
  • Biological Sensing
  • Nanopore Sequencing
  • Nanopore Sensing
  • Nanopore Diagnostics

Advantages

Using this approach BLMs are formed that support ion channel activity and are stable in excess of day one.

 

Inventors

Craig Aspinwall

Associate Professor Chemistry and Biochemistry, Biomedical Engineering

University of Arizona

Phone: 520-621-6338

Email: aspinwal@email.arizona.edu

 

Leonard Bright

Graduate Student Chemistry and Biochemistry

University of Arizona

Phone: 520-626-1335

Email: bright1@email.arizona.edu

 

Steven Saavedra

Professor Chemistry

University of Arizona

Phone: 520-621-9761

Email: saavedra@email.arizona.edu

 

Contact

Paul Eynott

Licensing Manager, College of Science

University of Arizona, Tech Launch Arizona

PaulE@tla.arizona.edu

O: 520-626-1557 C:520-471-2687

 

Stage of Development

Proof of Concept: Partially Demonstrated

UA ID: UA14-172