Discovery of Novel Multivalent/Multifunctional Ligands With µ/d Opioid Agonist (µ-Preferring)/neurokinin 1 (Nk1) Antagonist Activities for the Treatment of Pain

Technology #ua15-049

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Researchers
Victor Hruby
Regents Professor Emeritus, Chemistry & Biochemistry
Aswini Giri
Assistant Research Scientist, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Invention:

The present invention is a novel peptide used in the treatment of chronic pain with opioid therapy with a reduction of unwanted side effect such as mental clouding, nausea and emesis, and constipation. These peptide-based ligands are able to interact with CNS receptors separately to produce a higher analgesic effect with no opioid-induced tolerance.   

Background:

Approximately 1.5 billion people worldwide suffer from chronic pain. Acute and chronic pain among military personnel and veterans is particularly prevalent, with some studies showing greater than 80% of Operation Enduring Freedom and Operation Iraqi Freedom vets suffering from chronic pain. Additionally, almost 30% of veterans seek treatment for chronic pain. Opioids are currently the primary treatment option for veterans suffering from chronis pain due to severe injuries, post-traumatic stress disorder (PTSD), and traumatic brain injury (TBI). The opioid therapy is accompanied with serious unwanted effects that makes the patient’s life miserable. 

 

Application:

This invention may be used to treat pain, especially chronic pain. 

 

Advantages:

This invention has been demonstrated to be outstanding in several fields, such as:

• Longer In-vitro Metabolic stability

• Higher Lipophilicity

• Better Biological profiles

• Better synergistic effect

 

Lead Inventor:

Giri, Aswini, Hruby, Victor

 

Contact:

Paul Eynott

Licensing Manager, College of Science

University of Arizona, Tech Launch Arizona

paule@tla.arizona.edu

TLA Ofc: 580-626-1557

 

UA ID: UA15-049