Discovery of a Multifunctional Ligand for Pain Relief

Technology #ua15-050

Questions about this technology? Ask a Technology Manager

Download Printable PDF

Categories
Researchers
Victor Hruby
Regents Professor Emeritus, Chemistry & Biochemistry
Aswini Giri
Assistant Research Scientist, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Invention

This technology is the discovery of a potent ligand, AKG177, with a balanced agonist activity with the two opioid receptors and antagonist activity at the neurokinin 1 receptor. The N-terminus was modified with an amino acid at the address region, enhancing receptor activity while binding to neurokinin 1. The blocking of the neurokinin 1 receptor can manage opioid tolerance, but studies show effectiveness is still retained when compared to morphine.

Background

Pain is mediated through receptors for opioid drugs. Neurokinin 1 is the receptor for substance P, which is responsible for escalating pain and an important factor in opioid-induced hyperalgesia. Hyperalgesia is the increased sensitivity of pain. Marketed as a novel drug for pain management or to interested drug companies

Advantages

  • The invention has an advantage over current opioids by avoiding tolerance and opioid-induced hyperalgesia.

Applications

  • Techniques and certain modifications may be useful to drug companies in order to improve tolerance for their existing opioid products.
  • Pharmaceutical companies looking to improve the side effects of their existing opioids.

Inventors

Aswini Giri

Victor Hruby

Contact

Paul Eynott

Licensing Manager, College of Science

PaulE@tla.arizona.edu

O: 520-626-1557