Expansible Ascending Aortic Graft

Technology #ua15-105

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Categories
Researchers
Scott Lick
Professor, Surgery
Richard Smith
Technical Director, Sarver Heart Center
Managed By
Rakhi Gibbons
Asst. Director, Life Sciences (520) 626-6695

Invention

This technology offers an expansible ascending aortic graft that allows for gradual expansion in systole and recoil in diastole, reducing blow flow turbulence and low-flow areas.

Background

Patients who suffer from senile aortic value stenosis often require aortic valve replacement. In many patients, concomitant aneurysmal disease requires the removal and replacement of the ascending aorta. Currently, the ascending aorta is often replaced with vascular grafts made of Dacron or poly-tetra-fluro-ethylene (PTFE). Despite their flexibility, these grafts have minimal compliance, leading to blood flow turbulence and low flow areas. Because the ascending aorta is responsible for roughly 50% of the impedance of the entire aorta, loss of the aortic wall expansion increases the cardiac workload. Therefore, an opportunity exists to develop a modified prosthetic that can improve cardiac function and reduce cardiac workload.

Applications

  • Utility for patients who are undergoing aortic valve replacement and require replacement of the ascending aorta due to concomitant aneurysmal disease.

Advantages

  • Allows the graft to expand in systole, and recoil in diastole, allowing for the absorption of roughly 25% of the left ventricular stroke volume
  • The graft is long enough distally to accept a coronary bypass graft proximal anastomosis
  • The graft ends can be trimmed to fit variations in size and geometry of the native aorta.

Inventors

Scott Lick

Richard Smith

Contact:

Rakhi Gibbons

Licensing Manager, Biomedical & Life Science

University of Arizona, Tech Launch Arizona

RakhiG@TLA.arizona.edu

O: 520-626-6695

Refer to technology # UA15-105