Method for Determining Cell Stiffness

Technology #ua15-179

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Researchers
Marvin Slepian
Professor, Medicine
Siu Ling Leung
Postdoctoral Research Associate I, Medicine
Managed By
Rakhi Gibbons
Asst. Director, Life Sciences (520) 626-6695

Title: Method for Determining Cell Stiffness

Invention: The present invention is a minimal-contact method used to trap and measure the stiffness of platelets in relation to the whole cell.

Background: Platelets, essential for hemostasis, are easily activated via biochemical and mechanical stimuli. In addition, cell stiffness is a vital parameter modulating the mechano-transduction of exogenous mechanical stimuli. This methodology seeks to address the gap in approaches of measuring individual platelet stiffness without inadvertent platelet activation.

Applications:

  • Hospital assessments (measuring cell stiffness)
  • Forensic medicine (determining cause of disease/impairment/death)
  • Biological research
  • Cancer research
  • Stem cell research

Advantages:

  • Employs dielectrophoresis-mediated electrodeformation
  • Facilitates further studies of mechanisms involved in mechanically-mediated platelet activation
  • Measures the mechanical properties of adherent, anchorage-dependent cells and anchorage-independent suspended cells that have limited shear sensitivity

Licensing Manager:

Rakhi Gibbons

RakhiG@tla.arizona.edu

(520) 626-6695