Novel microRNA Gene Expression Profiling for Sarcoidosis Diagnosis

Technology #ua15-193

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Categories
Researchers
Joe G.N. Garcia
Senior Vice President, Medicine
Tong Zhou
Research Assistant Professor, Medicine
Managed By
Rakhi Gibbons
Asst. Director, Life Sciences (520) 626-6695

Title: Novel microRNA gene expression profiling for sarcoidosis diagnosis

 

Invention: The invention is a microRNA (miRNA) regulated gene signature that can detect sarcoidosis in patients. The invention consists of 46 miRNAs and 1,559 genes that were differentially expressed with sarcoidosis severity. In addition, 17 genes were identified to form a diagnostic scale. A high score on the scale suggests a higher probability of complicated sarcoidosis.

 

Background: Sarcoidosis is a granulomatous lung disorder of unknown cause. The majority of individuals spontaneously recover with no side effects (uncomplicated sarcoidosis), but 20% of individuals experience major respiratory, cardiac, or nervous system complications (complicated sarcoidosis). Peripheral blood mononuclear cell gene expression profiling provides the opportunity to identify patients who are likely to develop complicated sarcoidosis.

 

Applications:

  • A service for providers to conduct a diagnosis of sarcoidosis

 

Advantages:

  • Detects sarcoidosis
  • Identifies individuals with complicated or uncomplicated sarcoidosis

 

Licensing Manager: 

Rakhi Gibbons

rakhig@tla.arizona.edu

(520) 626-6695