Novel microRNA Gene Expression Profiling for Sarcoidosis DiagnosisTechnology #ua15-193
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Title: Novel microRNA gene expression profiling for sarcoidosis diagnosis
Invention: The invention is a microRNA (miRNA) regulated gene signature that can detect sarcoidosis in patients. The invention consists of 46 miRNAs and 1,559 genes that were differentially expressed with sarcoidosis severity. In addition, 17 genes were identified to form a diagnostic scale. A high score on the scale suggests a higher probability of complicated sarcoidosis.
Background: Sarcoidosis is a granulomatous lung disorder of unknown cause. The majority of individuals spontaneously recover with no side effects (uncomplicated sarcoidosis), but 20% of individuals experience major respiratory, cardiac, or nervous system complications (complicated sarcoidosis). Peripheral blood mononuclear cell gene expression profiling provides the opportunity to identify patients who are likely to develop complicated sarcoidosis.
- A service for providers to conduct a diagnosis of sarcoidosis
- Detects sarcoidosis
- Identifies individuals with complicated or uncomplicated sarcoidosis