Synthesis of Dihydrofuran Compounds via an Anionic Annulation Approach

Technology #ua16-007

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Researchers
Isaac Chogii
Graduate Assistant, Chemistry & Biochemistry
Jon Njardarson
Professor, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Synthesis of Dihydrofuran Compounds vis an Anionic Annulation

 

Invention: The technology, at its core, is a novel synthetic method to add substituent groups to 2,5-dihydrofuran. It does so in a single pot reaction, requiring no additional transfers.

 

Background: Existing methods of producing substituted 2,5-dihydrofuran compounds usually involve metal catalysts or are multi-step syntheses. The invention does not involve the former and is not the latter. With a one pot synthetic method and no precious reagents, the invention is cost effective and fast.

 

Applications:

  • Production of Stavudine
  • Production of Manoalide
  • Cox-2 inhibitor compound development
  • Antifungal drug development

 

Advantages:

  • Cost effective, requiring no expensive reagents
  • One-Pot synthesis allows for production to occur within a single step once all reagents are added
  • Can be used to synthesize a variety of compounds so long as they share a 2,5-dihydrofuran core