Annulation to Produce Heterocyclic Compounds

Technology #ua16-019

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Researchers
Isaac Chogii
Graduate Assistant, Chemistry & Biochemistry
Jon Njardarson
Professor, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Novel Annulation Method for Pharmacological Compound Production 

Invention: The invention describes a novel way to generate heterocyclic compounds via a 3+2 annulation. This method requires no expensive reagents, and can be done in a chiral manner in some instances

Background: Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. The invention possess no such drawbacks and is able to create heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds.

Applications: Can be used to synthesize a variety of drugs conducive to

Anti HIV Compounds

Anti Hypertensive Compounds

Analgesics

Cancer Therapeutics

Advantages:

Cost effective relative to the existing options

One pot reaction, allowing for faster turnaround time

Can generate chiral compounds

Licensing Manager: 

Name: Paul R. Eynott PhD, MBA

Email: PaulE@tla.arizona.edu       

Phone: 520.471.2687

Website: http://techlaunch.arizona.edu/people/paul-eynott

Technology ID: UA16-019

Inventor(s): Jon Njardarson and Isaac Chogii