Novel Method for Synthesis of Indoles

Technology #ua16-022

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Researchers
Jon Njardarson
Professor, Chemistry & Biochemistry
Edon Vitaku
Graduate Assistant, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Novel Annulation Method for Pharmacological Compound Production 

 

Invention: The invention describes a novel method of generating heterocyclic compounds via a 3+2 annulation. This method does not require expensive reagents and, in some instances, can be completed in a chiral manner.

 

Background: Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. This invention possesses no such drawbacks and creates heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds.

 

Applications:

  • Anti-HIV compounds
  • Anti-hypertensive compounds
  • Analgesics
  • Cancer therapeutics

 

Advantages:

  • Cost effective relative to the existing options
  • One pot reaction allows for faster turnaround 
  • Generation of chiral compounds

 

Licensing Manager:

John Geikler

JohnG@TLA.arizona.edu

(520)626-4605