Fluorogenic Diazonium-Derived Fluorophores

Technology #ua16-038

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Researchers
John Jewett
Assistant Professor, Chemistry & Biochemistry
Bereketab Mehari
Graduate assistant, CBC
Mehrdad Shadmehr
Graduate Assistant, CBC
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Fluorogenic Diazonium-Derived Fluorophores

Invention: The technology describes various diazonium salts that can react to produce a fluorescent azobenzene compound.

Background: Current iterations of fluorescent diazonium salts utilize metal catalysts to produce a reaction. However, these metal catalysts can have harmful effects in a medical setting. This invention consists of a bioorthogonal approach performed under physiological conditions to produce fluorescent compounds that can be bound to specifically targeted proteins.  

Applications:

  • Biosensors
  • Detection and diagnostics
  • Medical imaging

Advantages:

  • Ideal for medical settings
  • Reduces the likelihood of false positives
  • Able to bind to various proteins,
  • Targets and detects a wide variety of compounds  

Licensing Manager:

Rakhi Gibbons

RakhiG@TLA.arizona.edu

(520) 626-6695