Pseudoprolines in NeuropeptidesTechnology #ua16-048
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- Robin Polt Professor, Chemistry & Biochemistry
- Evan Jones Graduate Assistant, Chemistry & Biochemistry
- Managed By
- Laura Silva
Title: Development of Novel Pseudopeptides
Invention: The invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects.
Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides, however, glycosylation plays a key role in manipulating the structure of existing peptides. This invention uses glycosylation to create a newly folded peptide that can then be used in a variety of pharmaceutical applications to produce medicinal effects.
- Targeted drug delivery
- Diagnostic imaging
- Increased capability to cross the blood-brain barrier
- Increased affinity to bind to specific targeted receptors
- Breakdown of the compound may not yield any toxic effects