Pseudoprolines in Neuropeptides

Technology #ua16-048

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Researchers
Robin Polt
Professor, Chemistry & Biochemistry
Evan Jones
Graduate Assistant, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Development of Novel Pseudopeptides

 

Invention: The invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects.

 

Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides, however, glycosylation plays a key role in manipulating the structure of existing peptides. This invention uses glycosylation to create a newly folded peptide that can then be used in a variety of pharmaceutical applications to produce medicinal effects.

 

Applications:

  • Targeted drug delivery
  • Biosensors
  • Diagnostic imaging

 

Advantages:

  • Increased capability to cross the blood-brain barrier
  • Increased affinity to bind to specific targeted receptors
  • Breakdown of the compound may not yield any toxic effects

 

Licensing Manager:

Rakhi Gibbons

RakhiG@TLA.arizona.edu

(520) 626-6695