Reactive Oxygen Species Gene Signature Predicts Survival in SepsisTechnology #ua16-068
Questions about this technology? Ask a Technology Manager
- Louise Hecker Assistant Professor, Medicine
- Marvin Slepian Professor, Medicine
- Christian Bime Assistant Professor, Medicine
- Tong Zhou Research Assistant Professor, Medicine
- Nima Pouladi Postdoctoral Research Associate I, Medicine
- Ting Wang Assistant Professor, Medicine
- Managed By
- Rakhi Gibbons Asst. Director, Life Sciences (520) 626-6695
Title: Reactive oxygen species gene signature predicts survival in sepsis
Invention: The technology is a 21-gene reactive oxygen species (ROS)-associated molecular signature that predicts survival in septic patients.
Background: Sepsis syndrome’s mortality rate is 26% to 82% depending on whether septic shock occurs. Currently there are no reliable diagnostic biomarkers available to predict survival of patients with sepsis. Furthermore, researchers at the University of Arizona understand there is evidence indicating oxidative stress plays a role in the pathogenesis of sepsis.
- Diagnostic tool and/or service for patients with sepsis
- Traditional biomarkers (C-reactive protein, interleukin-6, procalcitonin) are not reliable in predicting survival
- ROS-associated biomarkers were shown to predict the odds of patient’s outcome