Metformin Derivatives for a New Combination Therapy

Technology #ua16-107

Questions about this technology? Ask a Technology Manager

Download Printable PDF

Dong-Chul (Jeffrey) Pyun
Professor, Chemistry & Biochemistry
Theodore Price
Associate Professor
Gregory Dussor
Assistant Professor, Pharmacology
Dipti Tillu
Graduate Associate, Pharmacology
Bo Lian
Student Group D, Pharmaceutical Sciences
Managed By
Rakhi Gibbons
Asst. Director, Life Sciences (520) 626-6695


Faculty at the University of Arizona developed a novel therapeutic that targets the activation of a signaling pathway to treat both acute post-surgical pain and itch and prevent the transition to chronic pain. The invention contains a topical cream treatment at the incision site with either a commonly used, safe drug and/or a natural product that acts via the same pathway.

Dysregulated protein translation regulation pathways that underlie persistent pain states can be negatively regulated by activation of a particular signaling factor. The aim is to establish this signaling factor as a mechanism for the alleviation of post-surgical, and possibly other persistent pain. The inventors use two drugs that possess different mechanisms of this signaling activation to demonstrate a shared endpoint. A combination use of oral drug and topical cream containing the natural product may have wide applications for chronic post-surgical pain prevention.


Chronic pain following surgery is a major clinical issue. Between 10 to 50% of patient who have surgery develop chronic pain, which can be debilitating in 2 to 10% of these cases. Currently available therapeutics given for acute post-surgical pain do not always prevent the transition to chronic pain. Therefore, treatments that target the molecular pathology promoting post-surgical pain, particularly chronic pain, are needed.


  • Therapeutic targets a signaling factor that has not been used to treat pain
  • Has great potential to treat both acute and chronic post-surgical pain
  • The two compounds include a widely prescribed pharmaceutical product and the other being a natural product


  • Treatment of acute post-surgical pain and itch
  • Prevention of transition to chronic pain


Theodore J. Price


Paul R. Eynott PhD

Licensing Manager, Tech Launch Arizona