Detection of Protein Aggregation by Chemical Labeling

Technology #ua16-193

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Jacob Schwartz
Assistant Professor, Chemistry & Biochemistry
John Jewett
Assistant Professor, Chemistry & Biochemistry
Mahta Moinpour
Graduate Student, Chemstry & Biochemistry
Mehrdad Shadmehr
Graduate Assistant, CBC
Managed By
Laura Silva

Title: Diagnostic for ALS (Amyotrophic Lateral Sclerosis)


Invention: This technology is a novel method for detecting proteins that are associated with ALS. Because ALS produces proteins that form aggregates when the proteins should be free, inventors at the University of Arizona have developed chemical labels that can be used to determine if aggregates of these proteins are forming, indicating ALS.


Background: Current standards, such as El Escorial criteria, and methods of diagnosis lack sensitivity and are thus unable to quantify the progression of ALS in patients. In some cases, traditional diagnostics can result in certain subtypes of ALS going undiagnosed. The novel technology presented here addresses these issues by increasing the sensitivity and reliability of detecting proteins associated with ALS.


  • Identifying and quantifying ALS


  • Increased sensitivity and reliability
  • Does not require specialized equipment or training 


Licensing Manager:

Laura Silva

(520) 626-1557