A Method for Uncovering Cross-Linked Peptides by Mass Spectrometry

Technology #ua17-008

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Linda Breci
Associate Director, UA-Proteomics Consortium, Chemistry & Biochemistry
Jessica Wales
Gaduate Assistant, Chemistry & Biochemistry
William Montfort
Professor, Chemistry & Biochemistry
Managed By
Laura Silva

Title: Unique Process to Identify Drug Binding to Targets


Invention: The invention is a unique fragmentation pattern to identify cross-linked peptides in a mass spectrometer.


Background: Progress in drug discovery is generally hampered by a lack of understanding of how the medication works and how the drugs binds to its target. This technology provides a way to identify cross-linked peptides via a unique fragmentation pattern that aids in identifying the drug-binding region.



  • Drug discovery
  • Lab research tool



  • Allows for identification in complex mixtures (whole cells or tissues)
  • Provides an alternative unique fragmentation pattern to further research in medications' mechanism of action


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