Two-Component and Three-Component Nanoparticles for the Enhanced Stability and Delivery of Glycopeptide Drugs

Technology #ua17-039

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Researchers
Robin Polt
Professor, Chemistry & Biochemistry
Michael Heien
Associate Professor, Chemistry & Biochemistry
Jeanne Pemberton
Regents' Professor, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Two-Component and Three-Component Nanoparticles for the Enhanced Stability and Delivery of Glycopeptide Drugs

 

Invention: This technology is comprised of two-component and three-component nanoparticles that will aid in peptide drug delivery systems that are capable of penetrating the Blood Brain Barrier (BBB). This method extends the lifetimes of glycopeptide drugs, allowing them to reach the G protein coupled receptors in the brain to treat pathological conditions.

 

Background: Native peptides have poor metabolic stability, pharmacokinetics and pharmacodynamics (PK/PD). The PK/PD properties have been considerably improved by glycosylation. The enhanced formulation of these surface- active molecules to extend their lifetime in the bloodstream, and non- linear penetration of the BBB will overcome barriers that have thus far prevented adoption of glycopeptide drugs by the pharmaceutical industry.

 

Applications:

  • Treatment of manifold pathologies
  • Reduction of the effects of neurodegenerative diseases like Alzheimer’s and Parkinson’s
  • Treatment of chronic pain, depression and behavioral disorders

 

Advantages:

  • High specificity
  • High potency
  • Minimal predictable side effects
  • Potentially transformative in producing new drugs due to a large number of potential GPCR targets available

 

Licensing Manager:

Rakhi Gibbons

RakhiG@TLA.arizona.edu

(520) 626-6695