Water Soluble Nanoparticles for the Detection of Radioisotope Activity

Technology #ua17-080

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Colleen Janczak
Assistant Research Scientist, Chemistry & Biochemistry
Craig Aspinwall
Professor, Chemistry
Managed By
Laura Silva

Title: Water Soluble Nanoparticles for the Detection of Radioisotope Activity


Invention: The invention is scintillant nanoparticles (SNPs), which are core-shell nanoparticles for sensitive detection of radioisotope activity. These SNPs are made from a polystyrene core of variable diameter, with a thin silica shell deposited on the outside of the core. The hydrophobic matrix facilitates energy transfer from the radioisotope to the scintillant dye and increased solubility.


Background: Radioisotopes are used as molecular tracers in a variety of assays and liquid scintillation cocktails, which are molded polymers with dyes or inorganic glasses. The trouble with the current nanoparticles is the amount of waste and low penetration depth.



  • Research institutes who use liquid scintillation counting
  • Scintillation proximity assay companies
  • Imaging reagent companies



  • SNPs retain a one-year shelf life
  • SNPs require less liquid per test
  • SNPs reduce disposal costs
  • SNPs are compatible with current scintillation detector machines, reducing the need to upgrade


Licensing Manager:

Laura Silva


(520) 626-1557