Water Soluble Nanoparticles for the Detection of Radioisotope Activity

Technology #ua17-080

Questions about this technology? Ask a Technology Manager

Download Printable PDF

Categories
Researchers
Craig Aspinwall
Professor, Chemistry
Colleen Janczak
Assistant Research Scientist, Chemistry & Biochemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Water Soluble Nanoparticles for the Detection of Radioisotope Activity

 

Invention: The invention is scintillant nanoparticles (SNPs), which are core-shell nanoparticles for sensitive detection of radioisotope activity. These SNPs are made from a polystyrene core of variable diameter, with a thin silica shell deposited on the outside of the core. The hydrophobic matrix facilitates energy transfer from the radioisotope to the scintillant dye and increased solubility.

 

Background: Radioisotopes are used as molecular tracers in a variety of assays and liquid scintillation cocktails, which are molded polymers with dyes or inorganic glasses. The trouble with the current nanoparticles is the amount of waste and low penetration depth.

 

Applications:

  • Research institutes who use liquid scintillation counting
  • Scintillation proximity assay companies
  • Imaging reagent companies

 

Advantages:

  • SNPs retain a one-year shelf life
  • SNPs require less liquid per test
  • SNPs reduce disposal costs
  • SNPs are compatible with current scintillation detector machines, reducing the need to upgrade

 

Licensing Manager:

John Geikler

JohnG@TLA.arizona.edu

(520)626-4605