Radioisotope Responsive Nanomaterial for Detection of S35Technology #ua17-081
Questions about this technology? Ask a Technology Manager
- Colleen Janczak Assistant Research Scientist, Chemistry & Biochemistry
- Zeinab Mokhtari Graduate Assistant, 26 Chemistry & Biochemistry
- Craig Aspinwall Professor, Chemistry
- Managed By
- Paul Eynott Sr. Licensing Manager (520) 621-2878
Title: Radioisotope Responsive Nanomaterial for Detection of S35
Invention: The invention consists of thiol-functionalized nanoparticles for quantifying S35 cysteine. The S35 isotope is a better tracer for sensitive detection of sulfur-containing analytes and contributes to insight about the redox network of reactions inside cells.
Background: Cysteine is a small thiol that plays a role in multiple bio-mechanisms. Elevated levels of cysteine are often observed in patients with Alzheimer’s and Parkinson’s diseases. Current methods of measuring thiols are expensive, not sensitive, and can only be used in vitro. Therefore there is a need to create biosensors with the highest cell-permeability and lowest interference to measure thiols.
- Research laboratories
- Biotechnology companies
- Diagnostic assay companies
- Costs less than traditional methods (liquid scintillation cocktail, etc.)
- Provides increased compatibility with cellular intake due to the smaller volume
- Increases efficiency due to the higher surface area