Radioisotope Responsive Nanomaterial for Detection of S35

Technology #ua17-081

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Categories
Researchers
Colleen Janczak
Assistant Research Scientist, Chemistry & Biochemistry
Zeinab Mokhtari
Graduate Assistant, 26 Chemistry & Biochemistry
Craig Aspinwall
Professor, Chemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Radioisotope Responsive Nanomaterial for Detection of S35

 

Invention: The invention consists of thiol-functionalized nanoparticles for quantifying S35 cysteine. The S35 isotope is a better tracer for sensitive detection of sulfur-containing analytes and contributes to insight about the redox network of reactions inside cells.

 

Background: Cysteine is a small thiol that plays a role in multiple bio-mechanisms. Elevated levels of cysteine are often observed in patients with Alzheimer’s and Parkinson’s diseases. Current methods of measuring thiols are expensive, not sensitive, and can only be used in vitro. Therefore there is a need to create biosensors with the highest cell-permeability and lowest interference to measure thiols.

 

Applications:

  • Research laboratories
  • Biotechnology companies
  • Diagnostic assay companies

 

Advantages:

  • Costs less than traditional methods (liquid scintillation cocktail, etc.)
  • Provides increased compatibility with cellular intake due to the smaller volume
  • Increases efficiency due to the higher surface area

 

Licensing Manager:

Paul Eynott

PaulE@tla.arizona.edu

(520) 471-2687