Lipid Membrane Functionalized Nano-Scintillation Proximity Assay

Technology #ua17-084

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Categories
Researchers
Isen Andrew Calderon
Ph.D. Student, 26 Chemistry & Biochemistry
Colleen Janczak
Assistant Research Scientist, Chemistry & Biochemistry
Craig Aspinwall
Professor, Chemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Lipid Membrane Functionalized Nano-Scintillation Proximity Assay

 

Invention: The invention is a novel radioisotope detection assay that is compatible with intact lipid membranes, allowing membrane proteins to be used as sensors. The assay is made from polystyrene core with radioisotope-responsive scintillant fluorophores with a silica shell on the outside of the polystyrene core, which increases solubility.

 

Background: Scintillation proximity assays are used to detect beta particles from radiolabeled analytes. Membrane proteins are important in the study of a variety of diseases and critical development of drugs. Unfortunately, current available assays are unable to use membrane proteins because the particles are relatively large and high density.

 

Applications:

  • Pharmaceutical companies
  • Biotechnology companies
  • Diagnostic assay companies

 

Advantages:

  • Improves solubility with aqueous samples
  • Improves detection efficiency of low-energy beta particle emission
  • Uses phospholipid membrane coatings to maintain stability and functionality of membrane proteins
  • Lowers the cost of assay versus commercially available options

 

Licensing Manager:

Paul Eynott

PaulE@tla.arizona.edu

(520) 471-2687