Lipid Membrane Functionalized Nano-Scintillation Proximity Assay

Technology #ua17-084

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Isen andrew Calderon
Ph.D. Student, 26 Chemistry & Biochemistry
Colleen Janczak
Assistant Research Scientist, Chemistry & Biochemistry
Craig Aspinwall
Professor, Chemistry
Managed By
Laura Silva

Title: Lipid Membrane Functionalized Nano-Scintillation Proximity Assay


Invention: The invention is a novel radioisotope detection assay that is compatible with intact lipid membranes, allowing membrane proteins to be used as sensors. The assay is made from polystyrene core with radioisotope-responsive scintillant fluorophores with a silica shell on the outside of the polystyrene core, which increases solubility.


Background: Scintillation proximity assays are used to detect beta particles from radiolabeled analytes. Membrane proteins are important in the study of a variety of diseases and critical development of drugs. Unfortunately, current available assays are unable to use membrane proteins because the particles are relatively large and high density.



  • Pharmaceutical companies
  • Biotechnology companies
  • Diagnostic assay companies



  • Improves solubility with aqueous samples
  • Improves detection efficiency of low-energy beta particle emission
  • Uses phospholipid membrane coatings to maintain stability and functionality of membrane proteins
  • Lowers the cost of assay versus commercially available options


Licensing Manager:

Laura Silva

(520) 626-1557