Lipid Membrane Functionalized Nano-Scintillation Proximity AssayTechnology #ua17-084
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Title: Lipid Membrane Functionalized Nano-Scintillation Proximity Assay
Invention: The invention is a novel radioisotope detection assay that is compatible with intact lipid membranes, allowing membrane proteins to be used as sensors. The assay is made from polystyrene core with radioisotope-responsive scintillant fluorophores with a silica shell on the outside of the polystyrene core, which increases solubility.
Background: Scintillation proximity assays are used to detect beta particles from radiolabeled analytes. Membrane proteins are important in the study of a variety of diseases and critical development of drugs. Unfortunately, current available assays are unable to use membrane proteins because the particles are relatively large and high density.
- Pharmaceutical companies
- Biotechnology companies
- Diagnostic assay companies
- Improves solubility with aqueous samples
- Improves detection efficiency of low-energy beta particle emission
- Uses phospholipid membrane coatings to maintain stability and functionality of membrane proteins
- Lowers the cost of assay versus commercially available options