Rapid Conductance Based Analysis for Patch Clamp Sensors

Technology #ua17-085

Questions about this technology? Ask a Technology Manager

Download Printable PDF

Categories
Researchers
Craig Aspinwall
Professor, Chemistry
Steven Scott Saavedra
Professor, Chemistry & Biochemistry
Mark Agasid
Graduate Assistant, Chemistry
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Rapid Conductance Based Analysis for Patch Clamp Sensors

 

Invention: The invention is a data acquisition and analysis protocol for ligand-ion channel interactions. The approach allows for the quantification of ligand concentrations in less than 30 milliseconds. This approach can monitor rapid, dynamic chemical processes in a feasible manner.

 

Background: Ion channels have been researched as an option for label-free detection of analytes without optical or electrochemical activity. The process begins with binding of the target analyte to an ion channel to change the ion flux, which can be detected electrochemically. This is important in measuring dynamic biological processes that occur on the milliseconds to seconds timescale but unfortunately there has been little work done in creating ion channel sensors with rapid activity and sensitivity.

 

Applications:

  • Research centers
  • Academic laboratories
  • Biotechnology companies
  • Diagnostic assay companies

 

Advantages:

  • Provides faster data collection
  • Applicable to natural and artificial membranes
  • Protocol is repeatable with consistent results

 

Licensing Manager:

John Geikler

JohnG@TLA.arizona.edu

(520)626-4605