Amine to Alkene Conversion on Intact Proteins

Technology #ua17-087

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Diana Knyazeva
graduate student, 26 Chemistry & Biochemistry
Stephanie Jensen
graduate student (graduated), 26 Chemistry & Biochemistry
John Jewett
Assistant Professor, Chemistry & Biochemistry
Managed By
Laura Silva

Title: Amine to Alkene Conversion on Intact Proteins


Invention: This technology provides the ability to selectively convert lysine into a terminal alkene with aryl diazonium ions. Proteins can be selectively modified to make stapled cyclic peptides or other drug-like molecules.


Background: In 2015, the global protein therapeutics market grew to nearly $174.7 billion due to trends in targeted therapies that resulted in fewer side effects. Monoclonal antibodies and biologics are the largest portion of newer medications in development, leaving room for the development of novel pathways and techniques to fuel the creation of new therapies.



  • Pharmaceutical companies
  • Biotechnology companies
  • Diagnostic assay companies
  • Research centers
  • Academic laboratories



  • Provides a novel technique for pharmaceutical companies
  • Quick production/disposal


Licensing Manager:

Laura Silva

(520) 626-1557