Convenient 18F Radiolabeling of Biomolecular Agents

Technology #ua17-111

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Categories
Researchers
Mark Pagel
Professor, Medical Imaging
Iman Daryaei
Graduate Student
Abigail Shepard
Graduate student, Pharmaceutical Sciences
Managed By
Paul Eynott
Sr. Licensing Manager (520) 621-2878

Title: Convenient 18F Radiolabeling of Biomolecular Agents

 

Invention: A chemical synthesis method that utilizes a radioactive version of the Fluorine atom (18F) in order to conveniently and rapidly label biomolecules and other small molecules.

 

Background: A Positron Emission Tomography (PET) scan helps reveal how tissues or organs are functioning, specifically to detect certain cancers, heart disease, and brain disorders. A radioactive tracer is either injected, swallowed, or inhaled to detect higher levels of chemical activity in the body. The 18F atom (fluorodeoxyglucose) is widely used as the tracer, with this type of scan being referred to as FDG-PET. Current methods to synthesize the 18F atom are strenuous and sometimes require sophisticated radiochemistry expertise or an expensive cyclotron, a device used in the production of radionuclides. This new technology would increase the speed and simplify the synthesizing of 18F without requiring expertise or a cyclotron. This invention utilizes the readily available 18F throughout the US, with the closest source being in Phoenix.

 

Applications:

  • Diagnostics
  • Medical devices
  • Nuclear imaging

 

Advantages:

  • Increases speed and simplicity of synthesis
  • Does not require expertise or a cyclotron
  • Cheaper to implement

 

Licensing Manager:

Paul Eynott

PaulE@tla.arizona.edu

(520) 471-2687