Polarization and Phase MicroscopeTechnology #ua17-203
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Title: Polarization and Phase Microscope
Invention: This invention is a novel microscope capable of real-time polarization and phase measurements at a high resolution.
Background: Many biological samples involve 3D transparent objects that have similar absorbance and reflection based on their environment, making identification difficult. Conventional microscopy utilizes fluorescence staining and tagging to improve contrast of the sample and environment, however fluorescent agents are not perfect. Some issues involve photobleaching, cytotoxicity and a chance of disturbing cell behavior. Currently, no existing microscope can measure both polarization and phase properties without using two separate microscopes. This invention combines two complementary methods of phase and polarization imaging to measure all four properties of light interaction with the cell.
- Medical imaging
- Material identification
- Wavelength measurements
- Intensity measurements
- Polarization and phase measurements
- Ability to work in reflection and transillumination modes
- Suitable for polarization-resolved fluorescence imaging