Fast Volumetric Imaging of Fluorescent Tissue Structures and Activities

Technology #ua19-101

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Categories
Researchers
Dongli XU
Postdoctoral Researcher
Jun Ding
Asst. Professor, Neurosurgery
Leilei Peng
Assistant Professor, Optical Sciences
Managed By
Amy Phillips
Sr. Licensing Manager (520) 621-9579

Invention:

Researchers at the University of Arizona have developed a novel microscope imaging technique that generates high-resolution large-volume 3D images of tissue at subcellular resolution, and captures transient activities within the volume at 100 volume frames per second (vps).  The invention breaks away from the traditional plane-scanning approach and implements volumetric projection imaging instead.

Background:

In order to study complex dynamics of tissue in live animals, ideally the microscope needs to maintain the sub-micron resolution in deep tissue to resolve activities in subcellular structures, cover a large volume to analyze complex networks, and refresh the volumetric image at high speed to capture transient dynamics.  However, despite many processes, at present there are no known microscopic techniques that fully satisfy the need for resolution, penetration, volume and speed.

 

Applications:

•       Fast 3D subcellular imaging for organs, tissues, and other body parts

Advantages:

•       Intrinsic high 3D resolution

•       Simplified image processing

•       Faster frame rates; can accommodate movement in sample

•       Large image area/field of view

•       Twice the photon sensitivity for increased photon efficiency

 

Contact:  Amy Phillips

AmyP@tla.arizona.edu

Refer to case number UA19-101