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Polymerization of Lipid Assemblies in Aqueous Solution at Neutral pH
ua14-171 – The present invention provides compounds comprising a triazenylidene moiety and methods for producing and using such compounds Technology Background: Normally, polymerization of lipids involves the production of acidic side products (Srisiri 4866). Acidic conditions usually compromise protein bioactivity, rendering them useless when combined with the polymer. Invention: The invention... Read More
Synthesis of Chiral 3-Pyrrolines via an Anionic Annulation Approach
ua15-004 – Technology Background: There are seven main types of anti-hypertensives on the market now. The invention can help create either direct acting vasodilators or direct renin inhibitors. Invention: Invention consists of a novel method to access chiral 3-pyrroline products in one step. The treatment of a gamma leaving group with a strong base results in an anion. That anion can then be... Read More
Method for Detecting Iron-Specific Hypercoagulation
ua14-105 – This technology is a novel method for detecting clotting parameters related to iron-specific hypercoagulation in settings such as sickle cell disease, hemodialysis, mechanical circulatory support and repeated blood transfusions. Iron-mediated hypercoagulation is the result of increased plasma concentrations of iron. Utilizing information about the underlying molecular mechanisms of... Read More
Improvements Over Existing Methods/Devices/Materials Related to the Discovery of Novel Multivalent/Multifunctional Ligands With Agonist Activities at Opioid Receptors and Antagonist Activities at Nk-1 Receptor for the Treatment of Pain and Other Indi
ua14-103 – The invention describes a new ligand that has a very specific structure. It is cyclic in nature, making it more bioavailable, stable, and active in vivo. Furthermore it is comprised of unnatural amino acids, this confers specificity for NK-1 receptors. The compound antagonizes these receptors and makes them unavailable for use. It can be used as both an anti-inflammatory compound and an... Read More
A Gi-Specific Contrast Agent for Magnetic Resonance Imaging
ua12-105 – Background: Gastrointestinal (GI) radiography using barium contrast media has been widely used as a first-choice diagnostic imaging modality for detection of GI pathologies. Colonoscopy is the standard of care for colorectal cancer (CRC) screening. However, colonoscopy is an invasive procedure that requires intravenous sedation and suffers from patient noncompliance. CT colonography (CT-C)... Read More
FIB Aggregation
ua13-056 – This technology is a method of dynamically updating and aggregating changes to forwarding information base (FIB) in real time that is configurable depending on need of end user. By developing a more holistic and configurable approach to FIB aggregation and prioritization, this technology has proven ability to improve efficiency of both newer and older equipment as well as extend its... Read More
Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor
ua14-145 – Technology Description: The core portion of the dynorphin protein was identified and modifications were made to that core to allow dynorphin to interact and antagonize a bradykinin receptor which is partially responsible for pain sensations. Applications: Since the invention antagonizes a receptor partly responsible for pain, the modified protein can be used as a form of analgesic.... Read More
Amphipathic Helical Glycopeptide Address Sequences for Enhanced Blood-Brain Barrier Transport of Neuroactive Peptides
ua04-065 – Background: A common difficulty in targeting drug delivery to the brain is the inability of large chemical compounds to cross the blood brain barrier. Inventors have devised a helical glycopeptide carrier molecule with the ability to traverse the blood brain barrier enabling its use in a variety of pharmaceuticals. While 50% of alpha helices are known to be amphipathic and therefore potential... Read More
Utility of DNA Damage Markers in Prostate Cancer Diagnosis
ua13-140 – Title: Utility of DNA Damage Markers in Prostate Cancer Diagnosis Invention: The invention uses data from the expression of RAD51 (a marker of DNA repair and a cancer biomarker) and other selected biomarkers in prostate tissue samples to improve prostate cancer diagnoses. Increased expression of RAD51 has been associated with more aggressive forms of prostate cancer... Read More
Targeting the PH/DH Domain of Tiam1 for the Treatment And/or Prevention of Bone Metastases
ua13-105 – Prostate Cancer (PCA) is a heterogeneous disease and the 5-year survival rate for men whose cancer has metastasized at the time of diagnosis being 34%, however, if the cancer is detected prior to metastasis the 5-year survival rate increases to nearly 100%. Although most patients respond to androgen suppression by entering into clinical remission, they eventually develop more aggressive... Read More
Antidiabetic Drugs Confer Neuroprotection in a Drosophila Model of Amyotrophic Lateral Sclerosis Based on Tdp-43
ua13-078 – Six drugs belonging to three distinct classes of compounds have shown promise in the treatment of Amyotrophic Lateral Sclerosis (ALS) like symptoms in a drosophila model that approximates the important pathological characteristics of the disease. These drugs are promising candidates for use in mammalian models, in clinical trials, and eventually as potential future treatments for ALS. ... Read More
A Novel Gd-Sucrose Scaffold for Oral Administration in Mr-Colonography at 7 T
ua14-157 – 50,000 people died of colon cancer in 2014, making it the second leading cause of cancer morbidity in the United States. This has led the American Cancer Society to recommend regular colonoscopy for people over 50, as a means of early detection. However compliance has been underwhelming due to the invasive and unpleasant nature of the screening and prepatory phases. A less invasive method... Read More
Virtual Kernel Using Shared Memory
ua14-056 – The invention describes a kernel that resides within the processes that it manages, making it process specific. It accomplishes this through the application of sub-contexts. These sub-contexts allow the machine to call system functions directly, while incurring little process overheads that are normally associated with such actions . Lastly, they protect memory blocks so that no unauthorized... Read More
A Broadband Apparatus for Generating and Sampling Polarization States
ua13-104 – Researchers at the University of Arizona have developed thin-film polarization devices that generate and/or sample light-polarization states over a broad band (wide wavelength range) and over wide angles. The polarizers incorporate and exploit multiple polarization layer groups and can be integrated into a microarray and incorporated into a light source or a polarization camera. ... Read More
Novel Cleanroom With Life Support System for Experimentation in a Variety of Fields Including Ecology, Chemistry, and Biology
ua14-092 – Invention: The invention is a new device for environmental control that uses a series of compartments subdivided into uniquely suited sections making this device entirely modular. Background Cleanrooms fall under two broad categories, conventional sterile rooms and mini environments. The present invention is a mini environment, that is, it has a precisely controlled amount of... Read More
Fast Quantitative Magnetic Resonance Imaging
ua14-093 – The field of MRI concerned with generating quantitative maps of sample properties is known as quantitative MRI (QMRI). The use of QMRI in research and clinical practice constitutes a significant paradigm shift from the qualitative methods used to interpret property weighted images. Qualitative assessment methods are employed where images are sensitized or “weighted” to a particular property,... Read More
Solution-Processable Side-Strapped Phthalocyanines
ua14-120 – Title: Side-Strapped Phthalocyanines as Materials for Organic Electronics Invention: The invention describes a novel side-strapped derivative of pthalocyanine for use in photovoltaic cells to generate a current in a more efficient manner. We have a notice of allowance on US 14/672,124. Background: Within the context of photovoltaic solar power, there are other compounds based on the... Read More
Discovery of Novel Multivalent/Multifunctional Ligands With Agonist Activities at Opioid Receptors and Antagonist Activities at Nk-1 Receptor for the Treatment of Pain
ua14-054 – The invention describes a new ligand that has a very specific structure. It is cyclic in nature, making it more bioavailable, stable, and active in vivo. Furthermore, it is comprised of unnatural amino acids, this confers specificity for NK-1 receptors. The compound antagonizes these receptors and makes them unavailable for use. It can be used as both an anti-inflammatory compound and an... Read More
Discovery Program
ua13-097 – Background: QR code technology is used to engage people in exploration about the world. Families are introduced to the Discovery Program at a park’s information kiosk and are provided with 4 color-coded QR code options. These designate the four Discovery courses that are available. A QR-Reader application can be downloaded on any smart phone. This application allows for the scanning of a... Read More
Method for Guiding Cell Spreading in Automated Cytogenetics Assays
ua14-088 – The present invention presents a method and system for overcoming some of the intrinsic limitations that automated cytogenetic assays have by establishing a model whose parameters can be analyzed and controlled suitable for an automated system. The ability of characterizing fluid behavior at a scale comparable to the size of cells by interference fringes is expected to facilitate further... Read More
A Flexible Virtual Network With FIB Aggregation
ua14-063 – The technique of FIB aggregation reduces FIB size by combining entries whose prefixes are numerically aggregatable and whose next hops are the same. It is a software solution that can be applied to a single router without upgrading the hardware, changing the control plane, or affecting packets’ forwarding paths. Thus it can be deployed incrementally and selectively in a network at... Read More
iPlant Collaborative
mktp-11-001 – From the iPlant Website: iPlant is a community of researchers, educators, and students working to enrich all plant sciences through the development of cyberinfrastructure - the physical computing resources, collaborative environment, virtual machine resources, and interoperable analysis software and data services– that are essential components of modern biology. Until now, many of the... Read More
Levels of Emotional Awareness Scale - Electronic Version (Eleas)
ua13-061 – The Levels of Emotional Awareness Scale (LEAS) is a performance measure that assesses an individual’s ability to be aware his or her emotions. Emotional awareness is conceptualized as a cognitive skill that varies between individuals in the degree to which it has developed. People vary from one another in their typical level of emotional awareness. The five levels of emotional awareness... Read More
All-Fiber Multicore Fiber Laser Devices
ua06-059 – Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends of a piece of active multi-core fiber,... Read More
A Streamlined Process to Generate Nitroaromatic Compounds
ua14-077 – Title: A Streamlined Process to Generate Nitroaromatic Compounds Invention: Methods for nitration of aromatic compounds often include additives, such as zeolites, putative catalysts, and are carried out in a non-participatory solvent (1) . To add more than one nitro group, forcing conditions are often used. Mixtures often result, and the percent yield for a desired compound is sometimes low... Read More
Public Policy Handbook
ua14-080 – The Public Policy Handbook, published annually, will provide your students and graduates with resources for internships with think tanks, advocacy organizations, federal agencies and other institutions engaged in policy analysis and implementation. Students and career counselors have access to programs, deadlines, and applicant qualifications via a password protected website. The... Read More
Molecular Imaging of Cancer Cells in Vivo
ua14-073 – Molecular Imaging of Cancer Cells in Vivo The technology described is a non-invasive method of detecting cancer using in vivo probes that target and bind to receptor cites on or around the cancerous growth. One potential application would be to administer the proposed ligand in suspected cases of cancer to identify and confirm possible tumors. This fulfills the purpose of an optical... Read More
A Method for Drug Screening in Vivo Using a Drosophila Model of ALS
ua13-079 – UA13-079 is a method for performing drug screens to test candidate compounds for their therapeutic effectiveness in treating locomotor and neurodegenerative defects in a drosophila model of the human disease Amyotrophic Lateral Sclerosis (ALS). The drug screen consists of testing the ability of candidate compounds to rescue deleterious phenotypic effects induced by mutations/functional... Read More
Redox-Directed Chelators Targeting Intracellular Metal Ions
ua14-035 – Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, taking advantage of the reducing environment found in the cytoplasm of... Read More
A Colon-Specific Orally-Administered Drug Delivery Vehicle
ua13-111 – Title: Method and Compositions for Targeted Drug Delivery to the Lower GI Tract Invention: This technology is a new, orally administered pro-drug form of 5-aminosalicylic acid (5-ASA) that has been developed and successfully demonstrated. This invention relates generally to the field of medicine, and more specifically to methods and compositions for targeted delivery of substances to the... Read More
The Fluorescence Emission Spectrometer (Flores)
ua14-012 – UA14-012 Plant fluorescence and the advantages of sensing it using Fraunhofer lines has been known for years, however, the challenge has been to design an instrument that can measure the faint signals in the presence of full sunlight from space orbit. Space measurements to date have used only a few solar absorption lines or an oxygen absorption band near 760 nm, which does not allow... Read More
Mitogen-Activated Protein Three Kinase (Mtk1) as a Molecular Target
ua13-067 – Title: Mitogen-Activated Protein Three Kinase (MTK1) as a Molecular Invention: A drug screening assay that identifies compounds that inhibit MTK1 activity. This approach is more typical of drug screening efforts and most likely to yield compounds in a timely and facile manner. Background: MTK1 is a member of the MAP3K family of protein kinases. It is known that MKK6 is a protein that... Read More
Glycopeptides With Enhanced CNS Penetration for the Treatment of ALS
ua13-119 – Technology Title: PACAP-VIP Glycopeptides with Enhanced CNS Penetration for the Treatment of ALS Tech ID: UA13-119 Description: A new variation on the PACAP protein which can both agonize PAC1 receptors, causing neuro-protective effects, and antagonize VPAC receptors, causing anti-inflammation. Applications: This protein could be used as a potential treatment for Amyotrophic Lateral... Read More
Solid Phase Synthesis of Lanthanide Chelates
ua09-105 – Lesion size or volume prediction shortly after the beginning of an ablation procedure can inform and/or control the ablation process. The prediction and/or control is made without regard to an actual detected temperature in the vicinity of the ablation electrodes. As a consequence, the system has utility with irrigated catheter constructions and other situations in which local irrigation... Read More
Solid Phase Peptide Synthesis With Lanthanide-Mediated Phosphate Cleavage
ua09-106 – Background: Lanthanide chelates consists of a lanthanide ion that is tightly bound to a chelator, i.e., a carbon-based molecule that surrounds the lanthanide ion, which often has a basket-like conformation that forms a molecular container for the lanthanide ion. Lanthanide chelates have favorable properties for biomedical applications, such as biomedical imaging and radiotherapy. Solid Phase... Read More
Fmoc Solid Phase Synthesis With Metal Chelates
ua09-109 – Background: Metal ions are used as contrast agents for MRI, PET and SPECT imaging. To eliminate toxicity and/or to provide a mean to attach ligands t the metal, the metal is inserted into a basket-like molecule to form a metal chelate. One or more peptides may be added as a ligand to the metal chelate, to change the pharmacokinetics of the contrast agent or to detect cell receptors,... Read More
Embodied Conversational Agent-Based Kiosk for Automated Interviewing
ua12-064 – This technology is a complete system for automated interviewing suitable for credibility assessments and rapid screening. The system is completely integrated into either a standing or tabletop kiosk. Unlike current embodied conversational agent kiosks, this proposed ECA kiosk is equipped with behavioral and psychophysiological sensors such as: Vocal sensors (microphone, speech... Read More
Systems and Methods for Improving the Performance of a Photorefractive Device
ua10-027 – Background: Photorefractivity is a phenomenon in which the refractive index of a material can be altered by changing the electric field within the material, such as by laser beam irradiation. The change of the refractive index is achieved by a series of steps, including: (1) charge generation by laser irradiation, (2) charge transport, resulting in the separation of positive and negative... Read More
Formulaic Imaging for Tissue Diagnosis
ua12-086 – Formulaic video rate or still imaging provides maximal contrast between diseased tissue (lesions) and surrounding normal tissues, or between two different disease processes (such as cancer and inflammation), or between different grades of disease such as cancer, high grade dysplasia and low grade dysplasia (pre-cancer). Synthetic formulaic images are computed with the goal to provide... Read More
Optimization of Electrical Stimulation of Biological Material
ua13-019 – This invention proposes a number of improvements for retina nerve stimulation. These include: (1) a time profile for the stimulation current that leads predominantly to transversal stimulation of nerve cells; (2) auxiliary electric currents for electric field shaping with a time profile chosen such that these currents have small probability to cause stimulation; and (3) a local area... Read More
Optimization of Electrical Stimulation of Biological Material #2
ua13-025 – This invention proposes a number of improvements for retina nerve stimulation. These include: (1) a time profile for the stimulation current that leads predominantly to transversal stimulation of nerve cells; (2) auxiliary electric currents for electric field shaping with a time profile chosen such that these currents have small probability to cause stimulation; and (3) a local area... Read More
Combining Phase Measurements From Multiple MRI Channels
ua13-083 – This technology is the combination of multiple measurements obtained from different receive coils (channels) of an MR system to provide improved signal (SNR) via the improved sensitivity profile. The invention consists of an optimizer which determines the values of the echo time steps and the parameters of the post-processing algorithm. This optimizer need only to be run once, offline... Read More
Method and Device for Co-Culturing Human-Derived Cells Including Microorganisms for Monitoring Health or Disease States
ua12-020 – Background: A versatile microfluidic platform allowing co-culture of multiple cell populations in close proximity with separate control of their microenvironments would be extremely valuable for many biological applications. Invention: The present invention describes a method for co-culturing different species in close proximity that can allow, for example, the systematic... Read More
Plant Antimicrobial Washes for Use on Organic Leafy Greens
ua13-041 – Faculty at the University of Arizona are developing an antimicrobial wash solution for organic leafy greens by utilizing three plant essential oil formulations. The plant oils used for this invention are food compatible, natural and considered as generally safe. This technology is highly effective against antibiotic resistant salmonella enterica on organic leafy greens than current... Read More
Antimicrobial Efficacy of Treatments Based on Plant Compounds
ua12-015 – Researchers at the University of Arizona have demonstrated synergistic effects of silver and natural plant antimicrobials resulting in an effective, inexpensive, safe treatment with a wide variety of potential applications. Silver may be used as an alternative disinfectant in applications in which the use of traditional disinfectants such as chlorine may result in the formation of toxic... Read More
Improvements in and Relating to Analysis
ua11-030 – Background: Rapid DNA testing will apply to DNA forensics, food analysis, medical diagnostics, animal testing, security and homeland applications. Invention: A circuit board for interfacing with a sample cartridge, wherein the sample cartridge comprises a working surface defining a plurality of sections for processing a sample; wherein the circuit board is configured to be... Read More
Optical Design for the Volume Holographic Imaging System (Vhis) Endoscope
ua12-072 – This technology is a hand-held version of the Volume Holographic Imaging System (VHIS) microscope. It is suitable to use as an endoscope by a physician in a clinical setting. The invention extends the designed modular rigid endoscope system and can be used along a standard VHIS. The endoscope assembly is designed and allows usage for both volume holographic imaging and conventional white... Read More
Combination Treatment for Cancer Involving Cx-3543 and a PARP Inhibitor
ua06-073 – Researchers at the University of Arizona have discovered that the addition of benzamide to HeLA cells prior to treatment with CX-3543 results in an increase in nucleolin bound to the NHE III1 element of the c-Myc promoter. Further analysis of the data indicated that there is a significant increase in the induction of apoptosis over that of CX-3543 alone. This suggests that the combined use... Read More
Computer Assisted Surgical Trainer - Portable Version (cast-Pv)
ua11-139 – Title: Computer Assisted Surgical Trainer - Portable Version (CAST-PV) Invention: This technology is a construction kit that allows users to build a minimally invasive surgical (MIS) box trainer that provides a range of skills training. The trainer is portable, affordable and provides performance assessment software that can be downloaded to smart tablets and phones. Made with Lego... Read More
Gene Expression Predicts Seizure Outcome Following Temporal Lobectomy
ua13-115 – The function of this invention is to use expression of 6 individual genes and 6 biological process pathways derived from brain tissue of epileptic patients to predict which patients will continue to have seizures and those who will have remission of seizures following temporal lobectomy. The technology is a Gene Chip Probe Array containing the 6 genes discovered and are illustrated in... Read More