Search Results - carly+cabel

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Small Molecule DYRK/CLK Inhibitors and Uses Thereof
This invention is a new composition of matter spanning a 6,6-fused chemotype. The 6,6-analogs display strong inhibitory activity across protein kinases such as the DYRK family, including DYRK1A, DYRK2, and DYRK3, along with inhibiting CLK. The dual DYRK/CLK inhibitors have displayed activity in 3-D organoid models of glioblastoma. It is subsequently...
Published: 11/16/2023   |   Inventor(s): Christopher Hulme, Alessandra Fistrovich, Yeng Jeng Shaw, Sourav Banerjee, Curtis Thorne, Nathan Bedard, Carly Cabel
Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios
Rapid Image-Based Screening for Bioactive Compounds that Block SARS-CoV-2 Replication Cycle
This invention is a rapid image-based drug screening software platform for bioactive compounds that can block SARS-CoV-2 replication cycles. The invention utilizes a custom image processing algorithm that utilizes microscopy images to develop drug response profiles to identify lead compounds. This technology can also be used to neutralize antibodies,...
Published: 4/14/2023   |   Inventor(s): Curtis Thorne, Elaheh Alizadeh, Koenraad Van Doorslaer, Samuel Campos, Carly Cabel, Shuaizhi Li
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Software & Information Technology > Health IT