Search Results - kithsiri+wijeratne

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An Efficient And Improved Chemical Conversion Of The Natural Product Physachenolide D (LG-01) To Its Analogue LG-134 With Potent Anticancer Activity
Invention: An improved process of chemical conversion of the natural plant product physachenolide D (PCD) to a C-18 analogue (LG-134) of physachenolide C (PCC).Background: The standard yield of LG-134 using current methods is relatively low at 1/3 resultant from original products. This method allows for the yield to be double current chemical processes....
Published: 4/3/2023   |   Inventor(s): Leslie Gunatilaka, Kithsiri Wijeratne, Yaming Xu
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences > Therapeutics
Specific 17-Beta-Hydroxywithanolides Sensitize Cancer Cells to Apoptosis in Response to Toll-like Receptor (TLR)
This invention describes the use of physachenolide C for cancer treatment through cancer cell apoptosis (cell self-destruction) through extrinsic pathways of “death ligand” proteins. Physachenolide C is a natural product in which the 17-beta-hydroxy group and orientation of the molecule chain result in improved apoptosis sensitivity, with...
Published: 2/21/2024   |   Inventor(s): Leslie Gunatilaka, Yaming Xu, Kithsiri Wijeratne, Thomas Sayers, Poonam Tewary, Alan Brooks, Curtis Henrich, James McMahon
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios > Oncology
Semi-Synthetic 17beta-Hydroxywithanolides (17-Bhws) Promote Caspase-8-Dependent Apoptosis in Renal Carcinoma and Melanoma and Specifically Inhibit Human Prostate Cancer Cell Proliferation
This novel, partially naturally-derived compound can be used to treat three different kinds of cancer (melanoma, renal carcinoma, and prostate cancer) in patients without other treatment options. Background: The treatment of all kinds of cancers leaves much to be desired in terms of an efficient treatment that is highly effective and has comparably...
Published: 4/3/2023   |   Inventor(s): Leslie Gunatilaka, Kithsiri Wijeratne, Yaming Xu, Thomas Sayers, Poonam Tewary, Alan Brooks
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
A Water-Soluble Prodrug for the Heat Shock-Inducing Compound Withaferin A
University of Arizona researchers have developed an economically viable and environmentally friendly method for producing and isolating large quantities of both Withaferin A and the novel withanolides. Aeroponic cultivation is a significant achievement as acquiring an abundant supply of starting material is often a significant hurdle in the development...
Published: 4/3/2023   |   Inventor(s): Leslie Gunatilaka, Dennis Ray, Yaming Xu, Kithsiri Wijeratne
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
Natural Product Modulators of Stress Response
In response to many stresses, including heat, oxidizing conditions, and exposure to toxic compounds, plant cells up-regulate an evolutionarily conserved set of helper molecules known as heat shock proteins (Hsp). Increased expression of these proteins protects the organism against stress-induced damage. The investigators have isolated a secondary...
Published: 4/3/2023   |   Inventor(s): Leslie Gunatilaka, Luke Whitesell, Kithsiri Wijeratne, Thomas Turbyville
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics