Search Results - pain

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Small Molecule Therapeutics for L-DOPA-Induced Dyskinesia
This invention provides a novel therapeutic for the reduction of levodopa-induced dyskinesia associated with the treatment of Parkinson’s disease. This invention has been demonstrated to have a statistically significant effect upon dyskinesia compared to amantadine, the only drug currently given for dyskinesia treatment. This invention is for...
Published: 6/6/2023   |   Inventor(s): Ruben Vardanyan, Victor Hruby
Keywords(s): pain
Category(s): Technology Classifications > Life Sciences > Therapeutics
Discovery of Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor
This invention is a dynorphin analog designed to interact with a receptor that is partly responsible for pain sensations. Dynorphin analog targets the bradykinin receptors instead of the f NMDA receptors. The ligands are novel in the deletion of an arginine residue in position 7 which has been recognized as an essential residue for opioid and non-opioid...
Published: 4/3/2023   |   Inventor(s): Yeon Sun Lee, Victor Hruby, Josephine Lai, Frank Porreca
Keywords(s): [des-Arg7]-dynorphin analogs, amphipathic bradykinin receptor, non-opioid effect of dynorphin, pain, pharmacophore
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules