Search Results - pawel+kiela

5 Results Sort By:
Design and Synthesis of Pro-Drugs for Selective, Oral Delivery to the Gastrointestinal Tract
This invention provides a method for oral administration and targeted delivery of pro-drugs bonded to a carbohydrate-based molecular scaffold to the gastrointestinal tract, where the pro-drug is released directly in the gastrointestinal (GI) tract by nitroreductase enzymes naturally present. This technology provides a means of delivery of GI therapies...
Published: 7/15/2022   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
Novel 5-Fluorouracil Prodrug For Colorectal Cancer Therapy
This invention provides a method for a targeted delivery of a commonly used chemotherapy drug, 5-fluorouracil used to treat colorectal cancer. A pro-drug is released within the colon to release the active ingredient. The method will allow for targeted delivery of 5-fluorouracil to the colon. Background: Colorectal cancer is the third most commonly...
Published: 7/15/2022   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology
A Molecular Scaffold for Colonic Drug Delivery
A molecule which passes through the gastrointestinal tract was successfully synthesized and tested for GI MRI imaging in mice. A molecular scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. This contrast agent...
Published: 7/15/2022   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan, Suryakiran Navath, Venkataramana Rao, Rita Marie Woodford, Monica Midura-Kiela, Ahad Ali, Ramesh Alleti
Keywords(s): 5-aminosalicylic acid, gastrointestinal tract, inflammatory bowel disease, pro-drug
Category(s): Technology Classifications > Life Sciences > Diagnostics
Targeted Drug Delivery in the Gastrointestinal Tract, including for Inflammatory Bowel Disease
This invention is a scaffold molecule and a method for using the molecule to deliver active drug molecules to targets in the body. The sucrose-derived scaffold molecule delivers the drug to target sites and releases the drug molecules based on environmental factors, which improves efficacy and reduces side effects. Background: Throughout their research,...
Published: 7/15/2022   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics
Method and Compositions for Targeted Drug Delivery to the Lower GI Tract
This technology is a new, orally administered pro-drug form of 5-aminosalicylic acid (5-ASA) that has been developed and successfully demonstrated. This invention relates generally to the field of medicine, and more specifically to methods and compositions for targeted delivery of substances to the lower GI tract. The invention has particular utility...
Published: 7/15/2022   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan
Keywords(s): gastrointestinal tract, inflammation, inflammatory bowel disease, Life Sciences, molecular
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Drug Delivery