Search Results - samantha+harris

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Methods and Compositions for Rapidly Replacing Cardiac Myosin Binding Protein-C in Sarcomeres
This technology is designed to be directed to a recombinant protein comprising myosin binding protein (MyBP-C) with an internal insertion. The internal insertion will comprise of at least a portion of a split-protein pair adjacent to a protease recognition site where the internal insertion is within or between C1 and C8 domains of the MyBP-C protein....
Published: 1/25/2023   |   Inventor(s): Samantha Harris
Keywords(s):  
Category(s): Technology Classifications > Life Sciences
Myofilament Based Therapeutics for Cardiac Muscle Arrhythmias and Skeletal Muscle Tremors
This invention describes a novel therapeutic approach to treat cardiac muscle arrhythmias and skeletal muscle tremors. Background: Cardiac arrhythmias, such as those that cause atrial fibrillation or sudden cardiac death (SCD), are typically viewed as electrical/conduction abnormalities that drive uncoordinated heartbeats and their downstream health...
Published: 7/15/2022   |   Inventor(s): Samantha Harris
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Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences
A Cut and Paste Method for Modification of cMyBP-C in Muscle Sarcomeres
This technology utilizes unique “spy” proteins that allow researchers to effectively “cut and paste” desired cMyBP-C sequences that could include a variety of modifications such as point mutations and FRET probes. This method make the manipulation of cMyBP-C in thick filaments a lot easier. Background: cMyBP-C is an essential...
Published: 7/15/2022   |   Inventor(s): Samantha Harris
Keywords(s):  
Category(s): Technology Classifications > Research Tools