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Design and Synthesis of a New Class of G-Quadruplex-Binding Ligands for the Treatment of Cancer and Other Diseases
c-Myc is an essential transcription factor that plays an important role in cell proliferation, differentiation, as well as maintenance of other cell-cycle functions. Under pathologic conditions, c-Myc expression is highly elevated, contributing to development of malignancy in majority of human cancers. Thus researchers have been looking for compounds...
Published: 11/16/2023   |   Inventor(s): Laurence Hurley, Vijay Gokhale, Srinivasa Reddy Kota, Seongmin Hahn
Keywords(s): anticancer activity, G-quadruplex, quindolines
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics