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Using the Serum Phosphoproteome of Migraine Patients as a Theragnostic
Biomarkers for neurological disease are lacking. Preliminary data, using an in vitro model of the blood brain barrier has suggested that serum release of tight junction proteins and the associated phosphoproteome may have utility as a biomarker for headache presence (diagnostic), such as migraine, and in therapeutic effect (theragnostic). This invention...
Published: 1/24/2023   |   Inventor(s): Tally Largent-Milnes, Jared Wahl
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Category(s): Technology Classifications > Healthcare Portfolios
Cannulated Screw Tool Remover
This invention is a device that passes through a cannulated screwdriver and captures a loose cannulated screw so that it can be pulled back while turning the screwdriver to remove the screw. Cannulation of both the screwdriver and screw reduces the error and injury associated with moving instruments during surgery. It turns the device, screwdriver,...
Published: 1/27/2023   |   Inventor(s): Daniel Latt, Carlos Urrea-De La Puerta, Carolina Gomez Llanos, Emilio Araiza, Erick De Leon, Eva Richter
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Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Medical Devices
Mini-Sensor Suspension System for Supine CO2 Monitoring
A multi-CO2-mini-sensor-based monitoring system has been developed to measure the CO2 concentration of human respiratory gas around a subject’s face while the subject is in the supine position. According to the collected data, the system supports further analysis of human physical conditions such as sleep stage and quality. The mini-CO2 sensor...
Published: 9/7/2022   |   Inventor(s): Yijie Chen, Md Tariqul Islam, Young-Jun Son, Esther Sternberg
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Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Medical Devices
Non-Imaging, Random-Sampling Second Harmonic Generation Measurements to Distinguish Colon Cancer
Second-harmonic generation (SHG) microscopy has emerged as a powerful modality for imaging fibrillar collagen in a diverse range of tissues. A preliminary study demonstrated that non-imaging, randomly sampled SHG intensity measurements are likely sufficient to distinguish normal colorectal tissue from tumor/tumor-adjacent tissue with digital simulation...
Published: 12/1/2022   |   Inventor(s): Jenna Montague, Jennifer Barton, Hasina Shir
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Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Oncology
Methods and Materials for Modulating Construct Wear Due to Cyclic Loading
Rethinking the structural organization of a polymer is a normally forgone solution for improving polymer flexibility. Here, the inventors have created four improved ways to manufacture polymers. The first is to create it at its mid-stress point, the second is to make the polymer with a shifting neutral axis, the third method uses polymers to provide...
Published: 9/7/2022   |   Inventor(s): Marvin Slepian, Syed Hossainy
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Category(s): Technology Classifications, Technology Classifications > Materials > Biocompatible, Technology Classifications > Healthcare Portfolios, Technology Classifications > Medical Devices
Small Molecule DYRK/CLK Inhibitors and Uses Thereof
This invention is a new composition of matter spanning a 6,6-fused chemotype. The 6,6-analogs display strong inhibitory activity across protein kinases such as the DYRK family, including DYRK1A, DYRK2, and DYRK3, along with inhibiting CLK. The dual DYRK/CLK inhibitors have displayed activity in 3-D organoid models of glioblastoma. It is subsequently...
Published: 9/29/2022   |   Inventor(s): Christopher Hulme, Alessandra Fistrovich, Yeng Jeng Shaw, Sourav Banerjee, Curtis Thorne, Nathan Bedard, Carly Cabel
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Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios
A Small Molecule Kinase Inhibitor that Regulates RNA Degradation and Inhibits Tumor Growth and Invasion
This invention describes a novel potential therapeutic for several cancers that inhibits tumor growth and invasion by regulating RNA degradation. Background: There have long been attempts to find new cellular mechanisms that can be targeted for a wide range of cancers without the notable and significant toxic effects of existing therapies like chemotherapy...
Published: 7/15/2022   |   Inventor(s): Andrew Kraft, Koichi Okumura, Wei Wang, Giri Gnawali
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Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios
Peptides Targeting Inositols Mediated Proliferative Signaling for Treating Cancers and other Proliferative Disorders
This invention describes a method that efficiently stops the growth of cancer cells or over-proliferative cells without causing adverse cytotoxic effects on the body’s healthy organs and tissues. This technology focuses on the IMPA1/RAGE complex and its ability to control cell proliferation. Background: Proliferative disorders include a wide...
Published: 7/15/2022   |   Inventor(s): Olga Rafikova, Ruslan Rafikov
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios
Sex and APOE Genotype Precision Therapeutic Targets Discovery for Alzheimer’s Disease
This technology encompasses a formulation for patient subgroup-specific supplement for the treatment and therapy of Alzheimer's and other neurodegenerative diseases. These formulations can range in delivery method (food, drink, pill) and can be specific to patient subgroups. Background: Alzheimer’s disease is a progressive, neurodegenerative...
Published: 1/25/2023   |   Inventor(s): Rui Chang, Roberta Brinton, Kuixi Zhu, Rima Kaddurah-Daouk
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Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
Novel mRNA-based Prognostic Index Derived from Differential Expression Analysis Improves Overall Survival Estimates in Glioblastoma
This technology is a set of biomarkers to predict radiotherapy and chemotherapy outcomes in individual Glioblastoma Multiforme patients to better assess their prognosis and therapy. Background: Glioblastoma Multiforme (GBM) is the most aggressive form of brain cancer and is currently treated through surgical intervention, chemotherapy and radiotherapy....
Published: 7/15/2022   |   Inventor(s): Eric Weterings, Baldassarre Stea, Daruka Mahadevan, Michael Hammer, Christopher Morrison
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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios
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