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Peptides to Treat SARS-CoV, Pulmonary Hypertension and other Pulmonary Vascular Diseases
This innovation is centered around a peptide designed to interrupt the action of a protein called Aminopeptidase N (APN). This peptide functions as an antagonist or inhibitor, binding to the intracellular portion of APN. The primary focus of this technology is to treat pulmonary arterial hypertension (PAH) and viral infections, including COVID-19. PAH...
Published: 10/11/2023
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Inventor(s): Joel James, Ruslan Rafikov
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Therapeutics
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A Method of Treating Cardiomyopathy
This innovation is based on the finding that lack of Leiomodin-2 (Lmod2) is associated with cardiovascular issues, specifically enlarged heart or cardiomyopathy and it is better to have a truncated/mutated Lmod2 than zero or little Lmod2 present. A premature stop codon associated with Lmod2 causes truncation of Lmod2. This innovation is the use of antisense...
Published: 9/7/2023
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Inventor(s): Christopher Pappas
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios
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Leukocyte Gene Expression Predicts Human Temporal Lobe Epilepsy Seizure Frequency
The leukocyte gene biomarkers presented here identify totally new and different genes whose expression predict temporal lobe epilepsy (TLE) seizure frequency. This seizure frequency prediction is a manifestation of the underlying pathophysiology of TLE disease states which have, heretofore, not been identified to have a dichotomized genetic basis. Targeting...
Published: 9/7/2023
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Inventor(s): Martin Weinand
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Biomarkers
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Enhancing Absorption of Dietary Compounds to Promote Health
This innovation is directed to oral co-administration of glucuronidase and polyphenols for reabsorption in the gut. Glucuronidase are enzymes that can be made or derived from any source such as bacteria, recombinant, species agnostic, and others. The inactive glucuronides are cleared from the body by secretion back into the gastrointestinal track where...
Published: 10/2/2023
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Inventor(s): Janet Funk
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Healthcare Portfolios
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Wireless, Battery-Free, Subdermal Implantable Platforms for Transcranial and Long-Range Optogenetics
This invention is an improvement of current wireless subdermal implantable platform for long-range optogenetics and for transcranial implants without damaging brain tissue or using invasive surgical procedures. It uses capacitors and digital power management to deliver on-demand energy to the implant. This enables transcranial optogenetics stimulation...
Published: 8/9/2023
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Inventor(s): Philipp Gutruf
Keywords(s):
Category(s): Technology Classifications > Engineering & Physical Sciences > Communications & Networking > Wireless, Technology Classifications > Energy, Cleantech & Environmental > Energy Collection, Storage & Battery, Technology Classifications > Healthcare Portfolios
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Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...
Published: 7/6/2023
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Inventor(s): Rui Chang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 11/16/2023
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Inventor(s): Hongmin Li, Subodh Samrat, Zhong Li, Jia Zhou, Jimin Xu
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 11/16/2023
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Inventor(s): Hongmin Li, Zhong Li, Qing-yu Zhang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Wireless, Wearable NFC Enabled Power and Communication for Chronic Interfacing with Battery-Free Implants
This device will allow for long-term, secure, and reliable data collection from implantable biosensors in a simplified manner. An intended patient simply dons this device, and it will collect and transmit data indefinitely with no further interaction. This technology introduces a wireless, wearable, near-field communications (NFC)-capable device which...
Published: 4/3/2023
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Inventor(s): Philipp Gutruf, Kevin Kasper
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Engineering & Physical Sciences > Electronics
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Natural Compounds to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease.
Background:
Alzheimer’s disease (AD) is the most common form of dementia estimated to affect 36 million people worldwide and an estimated 115 million people by 2050. While doctors still don’t know the cause of AD, treatments...
Published: 6/3/2023
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Inventor(s): Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
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