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Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease.
Background:
Alzheimer’s disease (AD) is the most common form of dementia estimated to affect 36 million people worldwide and an estimated 115 million people by 2050. While doctors still don’t know the cause of AD, treatments...
Published: 5/17/2023
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Inventor(s): Rui Chang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/5/2023
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Inventor(s): Hongmin Li, Subodh Samrat, Zhong Li, Jia Zhou, Jimin Xu
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 4/3/2023
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Inventor(s): Hongmin Li, Zhong Li, Qing-yu Zhang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Wireless, Wearable NFC Enabled Power and Communication for Chronic Interfacing with Battery-Free Implants
This device will allow for long-term, secure, and reliable data collection from implantable biosensors in a simplified manner. An intended patient simply dons this device, and it will collect and transmit data indefinitely with no further interaction. This technology introduces a wireless, wearable, near-field communications (NFC)-capable device which...
Published: 4/3/2023
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Inventor(s): Philipp Gutruf, Kevin Kasper
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Engineering & Physical Sciences > Electronics
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Natural Compounds to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease.
Background:
Alzheimer’s disease (AD) is the most common form of dementia estimated to affect 36 million people worldwide and an estimated 115 million people by 2050. While doctors still don’t know the cause of AD, treatments...
Published: 6/3/2023
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Inventor(s): Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
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Using the Serum Phosphoproteome of Migraine Patients as a Theragnostic
Biomarkers for neurological disease are lacking. Preliminary data, using an in vitro model of the blood brain barrier has suggested that serum release of tight junction proteins and the associated phosphoproteome may have utility as a biomarker for headache presence (diagnostic), such as migraine, and in therapeutic effect (theragnostic). This invention...
Published: 4/3/2023
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Inventor(s): Tally Largent-Milnes, Jared Wahl
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios
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Cannulated Screw Tool Remover
This invention is a device that passes through a cannulated screwdriver and captures a loose cannulated screw so that it can be pulled back while turning the screwdriver to remove the screw. Cannulation of both the screwdriver and screw reduces the error and injury associated with moving instruments during surgery. It turns the device, screwdriver,...
Published: 4/3/2023
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Inventor(s): Daniel Latt, Carlos Urrea-De La Puerta, Carolina Gomez Llanos, Emilio Araiza, Erick De Leon, Eva Richter
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Medical Devices
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Mini-Sensor Suspension System for Supine CO2 Monitoring
A multi-CO2-mini-sensor-based monitoring system has been developed to measure the CO2 concentration of human respiratory gas around a subject’s face while the subject is in the supine position. According to the collected data, the system supports further analysis of human physical conditions such as sleep stage and quality.
The mini-CO2 sensor...
Published: 4/3/2023
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Inventor(s): Yijie Chen, Md Tariqul Islam, Young-Jun Son, Esther Sternberg
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Medical Devices
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Non-Imaging, Random-Sampling Second Harmonic Generation Measurements to Distinguish Colon Cancer
Second-harmonic generation (SHG) microscopy has emerged as a powerful modality for imaging fibrillar collagen in a diverse range of tissues. A preliminary study demonstrated that non-imaging, randomly sampled SHG intensity measurements are likely sufficient to distinguish normal colorectal tissue from tumor/tumor-adjacent tissue with digital simulation...
Published: 4/3/2023
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Inventor(s): Jenna Montague, Jennifer Barton, Hasina Shir
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Oncology
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Methods and Materials for Modulating Construct Wear Due to Cyclic Loading
Rethinking the structural organization of a polymer is a normally forgone solution for improving polymer flexibility. Here, the inventors have created four improved ways to manufacture polymers. The first is to create it at its mid-stress point, the second is to make the polymer with a shifting neutral axis, the third method uses polymers to provide...
Published: 4/3/2023
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Inventor(s): Marvin Slepian, Syed Hossainy
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Materials > Biocompatible, Technology Classifications > Healthcare Portfolios, Technology Classifications > Medical Devices
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