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Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/5/2023
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Inventor(s): Hongmin Li, Subodh Samrat, Zhong Li, Jia Zhou, Jimin Xu
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 4/3/2023
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Inventor(s): Hongmin Li, Zhong Li, Qing-yu Zhang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Decision Support Logic for Long QT
This technology is a clinical decision support system that can help to increase the awareness of the appropriate physician. This innovation can swiftly evaluate whether a patient’s heart rate is beating at an arrhythmic interval. This new clinical decision support system will be able to diminish the risk of sudden death due to inpatient cardiac...
Published: 4/3/2023
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Inventor(s): Steven Curry, Craig Heise, Tyler Gallo, Corneliu Antonescu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Health Education, Medical Training and Operations, Technology Classifications > Software & Information Technology > Databases & Data Mining, Technology Classifications > Software & Information Technology > Health IT
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Smart Programmable Ultraviolet Germicidal Irradiation System
This invention is a sanitizer that utilizes UV radiation to sanitize closed rooms. The invention will be able to be programmed and automated to precisely deliver the exact does of UV radiation around the area of interest while also considering safety. The sanitizer will irradiate UV light with multiple beam steering devices to selectively sterilize...
Published: 4/3/2023
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Inventor(s): Stanley Pau
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Imaging & Optics
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Use of DNA Containing Specific Sequences to Prevent Neisseria Gonorrhoeae Infection
This invention encompasses an antimicrobial that can treat disease caused by the pathogen Neisseria Gonorrhoeae (Ngo). The compounds described can be incorporated into commercially available personal lubricants for individual use.
Background:
N. gonorrhoeae (Ngo) causes over 160 million new cases of gonorrhea each year globally; in 2018, it caused...
Published: 4/3/2023
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Inventor(s): Magdalene So, Maria Rendon
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Genes and Polypeptides of Neisseria Musculi that can be used to Evaluate Vaccines and Anti-Bacterial Compounds against Infection by Pathogenic Neisseria Species
A set of Neisseria musculi (Nmus) genes have been identified which promote Nmus infection and persistence in its natural host, the mouse. These genes have never been described before, so the in-host function of their encoded proteins is unknown. These genes are present in the human pathogenic Neisseria, N. meningitidis and N. gonorrhoeae. These genes...
Published: 4/3/2023
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Inventor(s): Magdalene So, Katherine Rhodes, Maria Rendon
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics
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Direct Capture and Smartphone Quantification of Airborne SARS-CoV-2 on a Paper Microfluidic Chip
This is a rapid, handheld smartphone-based paper microfluidic assay that is capable of directly detecting SARS-CoV-2 in small droplets from the air, without the need for an air sampler or a long collection time. The infected droplets are collected on a paper microfluidic chip, which then has antibody-conjugated submicron fluorescent particle suspension...
Published: 4/3/2023
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Inventor(s): Jeong-Yeol Yoon
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Novel Antibiotic Drug Combination Including an Anti-Inflammatory Metabolite
This technology involves a combination of a metabolite, 3-hydroxyanthanilic acid (3HAA) with a compound that alters cellular iron homeostasis (e.g. an iron chelator or an iron supplement) that produces synergistic antibiotic interaction. 3HAA sensitizes bacteria to changes in iron availability (both increasing iron media content through supplementation...
Published: 4/3/2023
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Inventor(s): George Sutphin, Luis Espejo
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Covid-19 Time of Intubation Mortality Evaluation (C-TIME)
This invention describes software that uses a scoring system for calculating the probable mortality of patients with COVID-19 pneumonia at the time they require mechanical ventilation.
Background:
Worldwide there have been over 208 million cases of severe acute respiratory coronavirus 2 (SARS-CoV-2) and over 4.37 million of these cases resulted in...
Published: 5/10/2023
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Inventor(s): Craig Heise, Robert A. Raschke, Pooja Rangan, Sumit Agarwal, Suresh Uppalapu, Nehan Sher
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Healthcare Portfolios > Emergency Medicine
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A Microbiome Sparing, Organism-Specific Therapy for C. difficile Infection
University of Arizona researchers have developed a water-soluble nanocarrier that is non-toxic to both human tissue and to bacteria. The carrier can complex with oligonucleotides that can bind to bacterial mRNA, preventing translation and inhibiting various bacterial functions.
Background:
The carrier can complex with translation-inhibiting modified...
Published: 4/3/2023
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Inventor(s): David Stewart, Arun Sharma, Gayatri Vedantam
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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