|
Glycopeptide-Lipid Supramolecular Assembly
This invention provides an approach, including compositions and methods for delivering glycolipids to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin,...
Published: 3/15/2023
|
Inventor(s): Robin Polt, Michael Heien
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology
|
|
Plasma from Mouse Stroke Model that can be used to detect Neurofilament Light Chain
This invention relates to the intellectual property that consists of a stored archive of hundreds of mouse blood plasma samples that were taken from a laboratory stroke model for mice under various conditions of the mice age and the time past stroke. By evaluating the quantity of neurofilament light (NfL) chain (protein) within the samples they can...
Published: 3/6/2023
|
Inventor(s): Kristian Doyle, Jennifer Frye
Keywords(s):
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Neurology
|
|
Stroke Outcome Prediction using Vascular Imaging Features
This is a prediction method to determine the outcome of a stroke based on vascular images presented by the patient. This model predicts the 90-day functional outcome after ischemic stroke at a significantly higher accuracy than current models, to inform treatment decisions and patient selection. Machine learning models were employed and trained with...
Published: 3/6/2023
|
Inventor(s): Kaveh Laksari, Aditi Deshpande, Jordan Elliott, Pouya Tahsili-Fahadan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Diagnostics
|
|
Synapse Surgery Tools for Neural Circuit-Specific Synapse Ablation and Modification
Researchers at the University of Arizona have developed novel synapse manipulation tools, so called synapse surgery tools, using the endogenous synapse pruning system. Complement proteins tagging system for target synapses are effective in eliminating specific synapses relevant to neuronal functions and diseases. To accomplish this, the technology is...
Published: 3/6/2023
|
Inventor(s): Deveroux Ferguson, Hee-Dae Kim
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools
|
|
Blood Biomarker for the Diagnosis and Treatment of Chronic Inflammation in the Brain in the Days and Weeks after Stroke
This invention comprises a method of identifying chronic inflammation in the day(s), weeks, or months after a stroke by measuring matrix metalloproteinase-12 (MMP-12) in a patient to determine whether therapeutic intervention is required to help immune cells process lipid debris after stroke to reduce secondary neurodegeneration. MMP-12 is a protein...
Published: 2/10/2023
|
Inventor(s): Kristian Doyle
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Protein
|
|
Novel Peptides Bioavailable to the Brain for Non-Opioid Pain Relief and/or Addiction Treatment
Inventors at the University of Arizona have developed oxytocin analogues which have high potency, are designed to be more stable compared to the native oxytocin hormone (an endogenous peptide which inhibits pain and promotes social connection), have very high selectivity for oxytocin receptors, and are bioavailable for brain therapeutics. These druggable...
Published: 2/23/2023
|
Inventor(s): Lajos Szabo, Robin Polt, John Streicher, Michael Heien, Parthasaradhi Reddy Tanguturi
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
|
|
Small Molecules Targeting Protein-RNA Interactions in ALS and Related Neurodegenerative Diseases
This invention is an in silico molecule capable of mitigating locomotor dysfunctions through TDP-43 contained RNA remodeling.
Background:
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects the function of nerves and muscles. In the United States over 6,000 people are diagnosed each year with an estimated 15 cases diagnosed...
Published: 7/15/2022
|
Inventor(s): Daniela Zarnescu, May Khanna, Vijay Gokhale
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
|
|
Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 7/15/2022
|
Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
|
|
Selective Melanotropin Ligands for Neurodegenerative Diseases including Parkinson's
This technology involves administering an α-melanocyte-stimulating hormone through a carrier to selective melanotropin receptor ligands to treat neurodegenerative diseases. Specifically, this technology allows melanotropin to be administered through either one or both, the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R).
Background:
There...
Published: 7/18/2022
|
Inventor(s): Minying Cai, Victor Hruby
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Drug Delivery
|
|
New Strategies to Block RIPK1/3/MLKL-Mediated Neurodegeneration
University of Arizona researchers have discovered several small molecules that represent a new class of RIPK1/3 targeting therapeutics that can potentially be used in the treatment of Alzheimer’s Disease. These molecules inhibit necroptosis, which is a cell death pathway related to neurodegenerative diseases. Necroptosis is form of cell death...
Published: 12/1/2022
|
Inventor(s): May Khanna, Jonathan Sanchez, Vijay Gokhale, Salvatore Oddo
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
|
