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Optical and Acoustic Coupling Materials and Technologies
This invention describes materials and chemicals with novel, optimal optical and acoustic properties that enable or improve methods that require coupling of light and sound for biomedical and defense applications related to imaging and monitoring therapy. This invention overcomes current limitations by proposing optically and acoustically transparent...
Published: 7/27/2023
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Inventor(s): Russell Witte, Christopher Salinas, Eric Reichel
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Research Tools, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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Glycopeptide-Lipid Supramolecular Assembly
This invention provides an approach, including compositions and methods for delivering glycopeptides to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin,...
Published: 7/17/2023
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Inventor(s): Robin Polt, Michael Heien
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology
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Neonatal Anorectal Tonometer with Disposable/Detachable Tip
This technology is a neonatal anorectal tonometer that involves a detachable, fluid-filled tip with a quick release system involving (magnet & plate) that connects the tip to a force sensor inside the handle of the device. This device can be used as a substitute for digital rectal exams.
Background:
Cauda Equina Syndrome (CES) occurs when the Cauda...
Published: 4/3/2023
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Inventor(s): Eniko Enikov
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Emergency Medicine, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Sensors & Controls, Technology Classifications > Sensors & Controls > Motion & Force
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Stroke Outcome Prediction using Vascular Imaging Features
This is a prediction method to determine the outcome of a stroke based on vascular images presented by the patient. This model predicts the 90-day functional outcome after ischemic stroke at a significantly higher accuracy than current models, to inform treatment decisions and patient selection. Machine learning models were employed and trained with...
Published: 4/3/2023
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Inventor(s): Kaveh Laksari, Aditi Deshpande, Jordan Elliott, Pouya Tahsili-Fahadan
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Diagnostics
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Method for Diagnosing, Imaging, and Treating Overwhelmed Myelin Lipid Processing within Immune Cells in the Brain After Stroke
It was discovered that foam cells form within primary infarcts and areas of secondary neurodegeneration after stroke. This invention provides for a method of noninvasive imaging and assessment of fatty acid oxidation in the brain after stroke using radionuclide and magnetic resonance-based imaging currently used to measure myocardial fatty acid oxidation...
Published: 4/3/2023
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Inventor(s): Kristian Doyle
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics
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Treating or Preventing Anorexia Nervosa via Precision Targeting of Neuronal Circuit
This invention provides methods of treating one or more eating disorders, including anorexia nervosa, bulimia, and related clinical syndromes. A new treatment strategy has been discovered, comprising inhibiting two different neural circuits, which rescues all three of the activity-based anorexia (ABA) animal model phenotypes of extreme increases in...
Published: 4/27/2023
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Inventor(s): Haijiang Cai, Wesley Schnapp
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Life Sciences > Therapeutics
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Synapse Surgery Tools for Neural Circuit-Specific Synapse Ablation and Modification
Researchers at the University of Arizona have developed novel synapse manipulation tools, so called synapse surgery tools, using the endogenous synapse pruning system. Complement proteins tagging system for target synapses are effective in eliminating specific synapses relevant to neuronal functions and diseases. To accomplish this, the technology is...
Published: 7/28/2023
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Inventor(s): Deveroux Ferguson, Hee-Dae Kim
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools
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Iron-targeting to stop cancer growth in malignant cells
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Following cellular uptake, the tetrazolium...
Published: 8/31/2023
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Inventor(s): Elisa Tomat, Zoufeng Xu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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MC4R Selective Ligand for Obesity and Alzheimer’s Disease Prevention
This technology is a novel peptide that has been shown to be a potent MC4R selective antagonist. It is a potential therapeutic for cognitive loss and obesity.
Background:
The challenges of neurodegradation, Alzheimer’s disease, and obesity have been shown to have some similar molecular signatures that contribute to disease and have thus created...
Published: 4/3/2023
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Inventor(s): Minying Cai, Victor Hruby
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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Small Molecule Mixed Agonist/Antagonist for Opioid Receptors for Anti-Addiction and/or Pain Therapy
This invention provides compositions and method of pain treatment using a mixture of an opioid receptor agonist in combination with an adrenoreceptor modulator compound. The opioid receptor agonist may be a clinically-used drug, and the adrenoreceptor modulator compound is a novel small molecule. Proof-of-concept testing in animals has shown...
Published: 4/3/2023
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Inventor(s): Iman Daryaei, John Streicher, Abigail Schwarz
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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