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Tetrazolium-Based Pro-Chelators as New Anticancer Agents
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Background: Iron is an essential...
Published: 8/11/2022   |   Inventor(s): Elisa Tomat, Zoufeng Xu
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
MC4R Selective Ligand for Obesity and Alzheimer’s Disease Prevention
This technology is a novel peptide that has been shown to be a potent MC4R selective antagonist. It is a potential therapeutic for cognitive loss and obesity. Background: The challenges of neurodegradation, Alzheimer’s disease, and obesity have been shown to have some similar molecular signatures that contribute to disease and have thus created...
Published: 7/27/2022   |   Inventor(s): Minying Cai, Victor Hruby
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
Small Molecule Mixed Agonist/Antagonist for Opioid Receptors for Anti-Addiction and/or Pain Therapy
This invention provides compositions and method of pain treatment using a mixture of an opioid receptor agonist in combination with an adrenoreceptor modulator compound. The opioid receptor agonist may be a clinically-used drug, and the adrenoreceptor modulator compound is a novel small molecule. ­Proof-of-concept testing in animals has shown...
Published: 1/4/2022   |   Inventor(s): Iman Daryaei, John Streicher, Abigail Schwarz
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Novel Small Molecule Compounds with Neuroprotective Potential in ALS and Related Neurodegenerative Diseases
This invention comprises a series of novel small molecule compounds developed at the University of Arizona and their method of use for the treatment of locomotor dysfunction associated with Amyotrophic Lateral Sclerosis (ALS) and other diseases associated with proteinopathy of a transactive response (TAR) DNA binding protein, TDP-43. Testing in a previously...
Published: 9/2/2021   |   Inventor(s): Daniela Zarnescu, Jon Njardarson, Isaac Chogii, David Smith, Edon Vitaku, Rachel Allen
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics
Neuroprotection via Glycosylated PACAP Analogues with Differentiated Selectivity toward PAC1 and VPAC1 > VPAC2
Inventors at the University of Arizona have developed glycopeptide analogues of PACAP which exhibit selective PAC1 and/or VPAC1 receptor activity with a reduced VPAC2 receptor activity as compared to native PACAP, an endogenous peptide hormone associated with neuronal tissue repair. Thus, these compounds have positive benefits of PAC1 and VPAC1 activation...
Published: 6/25/2021   |   Inventor(s): Robin Polt, Parthasaradhi Reddy Tanguturi, Christopher Apostol, John Streicher, Lajos Szabo
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Blood Biomarker for the Diagnosis and Treatment of Chronic Inflammation in the Brain in the Days and Weeks after Stroke
This invention comprises a method of identifying chronic inflammation in the day(s), weeks, or months after a stroke by measuring matrix metalloproteinase-12 (MMP-12) in a patient to determine whether therapeutic intervention is required to help immune cells process lipid debris after stroke to reduce secondary neurodegeneration. MMP-12 is a protein...
Published: 6/16/2021   |   Inventor(s): Kristian Doyle
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Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Protein
Oxytocin Analogues Bioavailable to the Brain for Non-Opioid Pain Relief and/or Addiction Treatment
Inventors at the University of Arizona have developed oxytocin analogues which have high potency, are designed to be more stable compared to the native oxytocin hormone (an endogenous peptide which inhibits pain and promotes social connection), have very high selectivity for oxytocin receptors, and are bioavailable for brain therapeutics. These druggable...
Published: 6/9/2021   |   Inventor(s): Lajos Szabo, Robin Polt, John Streicher, Michael Heien, Parthasaradhi Reddy Tanguturi
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Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Protein Structure Analysis using One-Step Tyrosine Conjugation
This invention includes methods and systems for detecting, comparing, or evaluating proteins in an folded conformation, a particular bound state, or an aggregate state, and methods and systems for comparing amounts of labeling of a protein in a natural or control conformation and a denatured conformation. The methods of this invention may be used for...
Published: 12/2/2020   |   Inventor(s): Jacob Schwartz, John Jewett, Mahta Moinpour
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Orphan Diseases, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Protein
Allosteric Modulators of TDP-43 for Treating Neurodegenerative Diseases
This invention is a small molecule drug, nTRD22, that can be used to treat currently incurable neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and potentially even Alzheimer’s disease (AD) and Parkinson’s disease (PD). This molecule targets the N-terminal domain (NTD) of the DNA binding...
Published: 10/6/2020   |   Inventor(s): May Khanna, Liberty Francois-Moutal, Niloufar Mollasalehi, Vijay Gokhale, David Scott, Judith Tello Vega, Haley Williams
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
Pharmaceutical and Nutraceutical Formulation Therapeutics for Alzheimer's Disease
This invention is a new formulation for the treatment of Alzheimer’s Disease. Through the application of a novel computational systems biology approach, the inventors have identified several therapeutic targets of single cell type and whole bulk tissue that contribute to Alzheimer’s Disease, which can be used individually or in combination...
Published: 9/1/2020   |   Inventor(s): Rui Chang, Patrick Ronaldson, Qianying He
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Category(s): Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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