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HIF-1alpha Phospho-T455 Antibody
­This invention relates to a polyclonal antibody against a novel phosphorylation site that is known to be correlated with increased tumor growth. Specifically, the antibody targets a phosphorylation site on HIF-1α which is controlled by PIM kinases. This invention can be used not only as a therapeutic against cancer but also potentially as...
Published: 4/19/2022   |   Inventor(s): Noel Warfel
Keywords(s):  
Category(s): Technology Classifications > Research Tools, Technology Classifications, Technology Classifications > Healthcare Portfolios > Oncology
Specific 17-Beta-Hydroxywithanolides Sensitize Cancer Cells to Apoptosis in Response to Toll-like Receptor (TLR)
This invention describes the use of withanolide E for cancer treatment through cancer cell apoptosis (cell self-destruction) through extrinsic pathways of “death ligand” proteins. Withanolide E is a natural product in which the 17-beta-hydroxy group and orientation of the molecule chain result in improved apoptosis sensitivity, with demonstrated...
Published: 1/19/2022   |   Inventor(s): Leslie Gunatilaka, Yaming Xu, Kithsiri Wijeratne, Thomas Sayers, Poonam Tewary, Alan Brooks, Curtis Henrich, James McMahon
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Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios > Oncology
Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action
This invention describes an inhibitor of eIF4A, which is a validated cancer drug target. The inventors describe a novel mechanism by which this inhibitor works. Background: Oncogenic, or cancer-causing pathways have long been challenging drug targets, especially for complex cancers. One protein complex called eIF4F is key to select oncogenic pathways...
Published: 12/6/2021   |   Inventor(s): Eli Chapman, Christopher Zerio
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Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology
Multispectral Cancer Imaging Instrument
This skin cancer detection invention works by illuminating the area in question and imaging it in several different spectral bands. The sampled bands are compared to a normal sample by a unique method. Normal and abnormal areas are then displayed in appropriate colors. Background: The standard testing and removal procedure for skin cancer is called...
Published: 11/4/2021   |   Inventor(s): William Wolfe, Nasser Peyghambarian
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Category(s): *Opt: Medical Instrumentation & Devices, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Healthcare Portfolios > Oncology
Personalized Medicine Software for Generating and Analyzing Genomic Sequence
UA21-131 and UA21-132 Two Patents Pending for SYSTEMS AND METHODS FOR GENERATING AND ANALYZING A CUSTOMIZED GENOMIC SEQUENCE FOR THERAPEUTIC APPLICATIONS Software: Proof of concept software funded by Tech Launch Arizona developed by a software company is fully functional and creates consistent accurate results. MAXX Py The MAXX.py script generates...
Published: 11/2/2021   |   Inventor(s): Adam Grant
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Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics
Peptide Therapeutic for Triple Negative Breast Cancer
This invention provides compositions and methods for treating breast cancer using peptides or peptide mimics that bind to epidermal growth factor receptor (EGFR) and enhance the trafficking of EGFR to lysosomes for destruction. This mode of action induces the degradation of EGFR, loss of cancer cell survival and migratory capacity, and induces tumor...
Published: 2/15/2021   |   Inventor(s): Joyce Schroeder
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
Semi-Synthetic 17beta-Hydroxywithanolides (17-Bhws) Promote Caspase-8-Dependent Apoptosis in Renal Carcinoma and Melanoma and Specifically Inhibit Human Prostate Cancer Cell Proliferation
This novel, partially naturally-derived compound can be used to treat three different kinds of cancer (melanoma, renal carcinoma, and prostate cancer) in patients without other treatment options. Background: The treatment of all kinds of cancers leaves much to be desired in terms of an efficient treatment that is highly effective and has comparably...
Published: 2/3/2021   |   Inventor(s): Leslie Gunatilaka, Kithsiri Wijeratne, Yaming Xu, Thomas Sayers, Poonam Tewary, Alan Brooks
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
Sphyingolipid-Derived Cancer Nanotherapeutics
This invention is an improvement to a commonly used drug delivery vehicle: liposomes. Liposomes, while useful for their improved pharmacokinetics, have not demonstrated significantly improved efficacy and patient survival. This may be in part due to the fact that generally only one drug can be loaded per liposome. However, this technology allows co-delivery...
Published: 1/20/2021   |   Inventor(s): Jianqin Lu
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
Innovative Approaches to Optimize the Therapeutic Benefit of Autophagy Inhibition
This invention is a set of novel synthetic compounds that demonstrates autophagy-inhibiting efficacy, useful for cancer and pulmonary hypertension treatment. Background: Autophagy is an evolutionarily conserved lysosomal protein degradation process. Aberrant autophagy plays a role in the pathogenesis of many health conditions including cancer, pulmonary...
Published: 10/6/2020   |   Inventor(s): Jennifer Carew, Steffan Nawrocki, Wei Wang
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Therapeutics
Design and Development of Innovative Formulations of Resatorvid for Targeted Skin Drug Delivery and Applications Therein
University of Arizona researchers have developed a novel formulation of Resatorvid, a selective TLR4 inhibitor that was originally designed for the treatment of sepsis. This re-formulation is designed for delivery to the skin for a variety of skin diseases including early stages of skin cancer. Background: Skin cancers tend to be slow growing and can...
Published: 8/3/2020   |   Inventor(s): Heidi Mansour, Victor Ruiz, Sally Dickinson, Clara Curiel, Hsiao-Hui Chow, Georg Wondrak
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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