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A Recombinant Protein to Restore the Anti-Cancer Activity of Immune Cells
This invention is a recombinant protein that is designed to restore the activity of immune cells that have been exhausted in patients with cancer. This invention focuses specifically on the restoration of the anti-cancer activity of immune cells, in particular natural killer (NK) cells.
Background:
Immune cell-based therapies are a widely utilized...
Published: 4/13/2023
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Inventor(s): Youngwook Won, Seungmin Han, David Bull
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Targeted Cancerous Cell Specific Suicide Gene Therapy
This invention describes a novel cancer therapy method that induces cell death mechanisms in only cancer cells.
Background:
The current standard of care for cancer therapy in many cases is chemotherapy. Chemotherapy, like many cancer treatments, causes significant amounts of healthy cells to die in addition to the cancer cells, leading to the well-known...
Published: 4/3/2023
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Inventor(s): Ravi Goyal
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Breast Density Assessment Device
This invention is a non-invasive, inexpensive, comfortable and portable diagnostic test to screen for breast cancer. Designed for early detection particularly among minority populations and as a preliminary screening tool before mammography or MRI assessment. Bioelectrical impedance analysis is a simple, quick, and non-invasive technique for measuring...
Published: 4/3/2023
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Inventor(s): Jennifer Bea
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices
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KM Cells - A Metastatic Cell Line and Method of Producing
In this study, researchers at the University of Arizona investigated an early cancer invasion event using a unique in vivo model. Muscle invasion was tested by the ability of prostate cancer cells to colonize the inferior surface of the respiratory diaphragm of male NGS mice, invade into and through to the superior surface. They isolated and compared...
Published: 5/2/2023
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Inventor(s): Kendra Marr, Anne Cress
Keywords(s):
Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences
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Human Colon Polyp Derived Organoid
This innovation is a patient-derived organoid that is used as a screening platform to study both tissues patterning and the kinase pathway dynamics in single cells across many conditions. Through this technology one is able to evaluate the patterning and homeostasis of the cells and tell when they are out of alignment. Through the use of this technology...
Published: 4/14/2023
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Inventor(s): Kelvin Pond, Curtis Thorne, Andrew Paek
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Research Tools > Cell Lines
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Peptide Therapeutic for Immune Response Activation against Metastatic Triple Negative Breast Cancer
This invention provides compositions and methods for treating triple negative breast cancer using peptides or peptide mimics that bind to epidermal growth factor receptor (EGFR) to block EGFR nuclear translocation. This mode of action alters EGFR-dependent gene transcription, induces the loss of cancer cell survival and migratory capacity, and...
Published: 4/3/2023
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Inventor(s): Joyce Schroeder, Angelica Escoto, Benjamin Atwell
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics
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Non-Imaging, Random-Sampling Second Harmonic Generation Measurements to Distinguish Colon Cancer
Second-harmonic generation (SHG) microscopy has emerged as a powerful modality for imaging fibrillar collagen in a diverse range of tissues. A preliminary study demonstrated that non-imaging, randomly sampled SHG intensity measurements are likely sufficient to distinguish normal colorectal tissue from tumor/tumor-adjacent tissue with digital simulation...
Published: 4/3/2023
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Inventor(s): Jenna Montague, Jennifer Barton, Hasina Shir
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Oncology
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Tetrazolium-Based Pro-Chelators as New Anticancer Agents
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types.
Background:
Iron is an essential...
Published: 4/3/2023
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Inventor(s): Elisa Tomat, Zoufeng Xu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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Specific 17-Beta-Hydroxywithanolides Sensitize Cancer Cells to Apoptosis in Response to Toll-like Receptor (TLR)
This invention describes the use of withanolide E for cancer treatment through cancer cell apoptosis (cell self-destruction) through extrinsic pathways of “death ligand” proteins. Withanolide E is a natural product in which the 17-beta-hydroxy group and orientation of the molecule chain result in improved apoptosis sensitivity, with demonstrated...
Published: 4/3/2023
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Inventor(s): Leslie Gunatilaka, Yaming Xu, Kithsiri Wijeratne, Thomas Sayers, Poonam Tewary, Alan Brooks, Curtis Henrich, James McMahon
Keywords(s):
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios > Oncology
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Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action
This invention describes an inhibitor of eIF4A, which is a validated cancer drug target. The inventors describe a novel mechanism by which this inhibitor works.
Background:
Oncogenic, or cancer-causing pathways have long been challenging drug targets, especially for complex cancers. One protein complex called eIF4F is key to select oncogenic pathways...
Published: 4/3/2023
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Inventor(s): Eli Chapman, Christopher Zerio
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology
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