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Fast Volumetric Imaging of Fluorescent Tissue Structures and Activities
Researchers at the University of Arizona have developed a novel microscope imaging technique that generates high-resolution large-volume 3D images of tissue at subcellular resolution, and captures transient activities within the volume at 100 volume frames per second (vps). The invention breaks away from the traditional plane-scanning approach and implements...
Published: 7/14/2022   |   Inventor(s): Leilei Peng, Jun Ding, Dongli XU
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Camera-Based Surgical Microscope with Display
This invention is a compact surgical microscope that provides an increased depth of focus and wide field of view from various angles of the surgical field. Information from multiple wavelengths, including visible and NIR can be overlaid on a single display monitor. The monitor is mounted so that several people can view it at the same time, with no neck...
Published: 7/14/2022   |   Inventor(s): Rongguang Liang
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
A Multi-Functional Three-Dimensional Microscopic System with Structured Illumination and Optical Depth Scanning
This technology is a telecentric microscope design that reconciles the resolution vs. depth of field issues associated with microscope systems. The microscope's design maintains constant system magnification while it performs a depth scan with an electrically controlled vari-focal lens. Background: The classic tradeoff between optical resolution...
Published: 7/14/2022   |   Inventor(s): Hong Hua, Sheng-Huei Lu
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 7/14/2022   |   Inventor(s): Leilei Peng, Yu Li, Han Zhang
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Method of Simultaneous Frequency-Sweeping Lifetime Measurements on Multiple Excitation Wavelengths
A new lifetime imaging system that can fully measure the FRET network between five fluorescent labels in a single image scan has been developed at the University of Arizona. This technology is capable of performing hyper-dimensional lifetime imaging on multiple excitation wavelengths simultaneously, allowing for previously not achievable FRET imaging...
Published: 7/14/2022   |   Inventor(s): Leilei Peng, Ming Zhao
Keywords(s): fluorescence lifetime, frequency-sweeping
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Imaging & Optics
Frequency Domain Reconstruction System for Microgrid Imaging Polarimeters
Researchers at the University of Arizona have developed the concept for a camera system that is able to perform polarimetric imaging with ease while simultaneously implementing instrumentation that reduces polarization artifacts. The system uses technology currently existing in handheld cameras to perform polarization imaging in a novel way that allows...
Published: 7/14/2022   |   Inventor(s): J. Scott Tyo, Bradley Ratliff
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging
Parallel Multi-Point Scanning Confocal Imaging
Researchers at The University of Arizona's James C. Wyant College of Optical Sciences have designed a confocal microendoscopic multi-point scanning system. This system has approximately the same resolution of a single point scan system while maintaining the high frame rate of the slit-scan system at 30 fps. A prototype has demonstrated that for...
Published: 7/14/2022   |   Inventor(s): Arthur Gmitro, Andrew Rouse, Anthony Tanbakuchi
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Imaging & Optics
Quantitative Large Area Binding Sensor For Detecting Biomarkers
Researchers at the University of Arizona have developed a lens-free holographic microscope (LFHM) for observing and quantifying target biomarkers in a solution, including targets with a large dynamic range in concentration. LFHM can be used to detect microscale targets (e.g., bacteria and cells) and nanoscale targets (e.g., viruses, DNA strands, and...
Published: 7/14/2022   |   Inventor(s): Euan Mcleod, Zhen Xiong
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging
Multi-Resolution Foveated Laparoscope
Researchers at the University of Arizona have developed an optical design for laparoscopes that can obtain wide angle and high magnification images of a surgical area in real time. The two images enable seamless registration between the low and high-resolution images, providing surgeons with the best of both worlds. In addition, the innovation enables...
Published: 7/14/2022   |   Inventor(s): Hong Hua, Mike Nguyen, Yi Qin
Keywords(s): foveated imaging, laparoscope, multi-resolution
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics
Time-Resolved Fluorescence Measurements in Real-Time
A prototype instrument that uses fast switching photomultiplier tube (PMT) to acquire real-time time-resolved fluorescence lifetime data has been developed and tested at the University of Arizona. The PMT detector can collect fluorescence data at rates as high as 200 MHz without the production of switching transients. The circuit system also demonstrates...
Published: 7/14/2022   |   Inventor(s): Linda Powers, Jerrie Fairbanks, Varun Sridharan, Xiang Zhang, Xavier Ramus, Andrew Duncan
Keywords(s): fluorescence, high NA, high speed data collection, real-time data collection, time-resolved data collection
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics
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