Search Results - technology+classifications+%3e+life+sciences

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Methods and Compositions for Rapidly Replacing Cardiac Myosin Binding Protein-C in Sarcomeres
This technology is designed to be directed to a recombinant protein comprising myosin binding protein (MyBP-C) with an internal insertion. The internal insertion will comprise of at least a portion of a split-protein pair adjacent to a protease recognition site where the internal insertion is within or between C1 and C8 domains of the MyBP-C protein....
Published: 1/25/2023   |   Inventor(s): Samantha Harris
Category(s): Technology Classifications > Life Sciences
Novel Main Protease Inhibitors as SARS-CoV-2 Antivirals
This technology encompasses the development of novel inhibitors for the main protease, or Mpro, of SARS-CoV-2. The main protease of SARS-CoV-2 is a validated drug target and could be key to the development of antiviral drugs against the virus. The inhibitors proposed in this technology are notable, as they are potent main protease inhibitors with high...
Published: 12/21/2022   |   Inventor(s): Jun Wang
Category(s): Technology Classifications > Life Sciences
KM Cells - A Metastatic Cell Line and Method of Producing
In this study, researchers at the University of Arizona investigated an early cancer invasion event using a unique in vivo model. Muscle invasion was tested by the ability of prostate cancer cells to colonize the inferior surface of the respiratory diaphragm of male NGS mice, invade into and through to the superior surface. They isolated and compared...
Published: 12/6/2022   |   Inventor(s): Kendra Marr, Anne Cress
Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences
Synapse Surgery Tools for Neural Circuit-Specific Synapse Ablation and Modification
Researchers at the University of Arizona have developed novel synapse manipulation tools, so called synapse surgery tools, using the endogenous synapse pruning system. Complement proteins tagging system for target synapses are effective in eliminating specific synapses relevant to neuronal functions and diseases. To accomplish this, the technology is...
Published: 11/21/2022   |   Inventor(s): Deveroux Ferguson, Hee-Dae Kim
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools
Vascular Plug
This technology is a small silicon item that is designed to fit in blood vessels to stop blood loss by plugging the vessels to allow for ligation of the vessel during surgical procedures. Prototypes of two durometers have been made. These plugs will come in slightly varied sizes to allow them to fit in any vessel. Background: The World Health Organization...
Published: 8/19/2022   |   Inventor(s): Craig Weinkauf, Scott DeRigne
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Medical Devices
Amphipathic Helical Glycopeptide Address Sequences for Enhanced Blood-Brain Barrier Transport of Neuroactive Peptides
University of Arizona researchers have successfully created a series of amphipathic helical glycopeptides with the ability to retain a membrane bound conformation promoting endocytosis as well as a water-soluble conformation facilitating exit from the membrane. This "biousian" property is intrinsic in allowing the molecule to traverse the...
Published: 7/15/2022   |   Inventor(s): Robin Polt, Dhanasekaran Muthu
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Engineering & Physical Sciences
Sex and APOE Genotype Precision Therapeutic Targets Discovery for Alzheimer’s Disease
This technology encompasses a formulation for patient subgroup-specific supplement for the treatment and therapy of Alzheimer's and other neurodegenerative diseases. These formulations can range in delivery method (food, drink, pill) and can be specific to patient subgroups. Background: Alzheimer’s disease is a progressive, neurodegenerative...
Published: 1/25/2023   |   Inventor(s): Rui Chang, Roberta Brinton, Kuixi Zhu, Rima Kaddurah-Daouk
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
Peptide-Based Modulators of HMGBl Activity Protect Against Cell Damage and Inflammation
This technology assists with the inhibition of HMGB1 to decrease the body’s inflammatory response which occurs when the HMGB1 protein binds to DNA and TLR4. By decreasing HMGB1 binding to DNA, cell inflammation can be significantly reduced, thus preventing further cell damage. This technology can be used in a large spectrum of diseases, such as:...
Published: 7/15/2022   |   Inventor(s): Ruslan Rafikov, Olga Rafikova
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation
Novel mRNA-based Prognostic Index Derived from Differential Expression Analysis Improves Overall Survival Estimates in Glioblastoma
This technology is a set of biomarkers to predict radiotherapy and chemotherapy outcomes in individual Glioblastoma Multiforme patients to better assess their prognosis and therapy. Background: Glioblastoma Multiforme (GBM) is the most aggressive form of brain cancer and is currently treated through surgical intervention, chemotherapy and radiotherapy....
Published: 7/15/2022   |   Inventor(s): Eric Weterings, Baldassarre Stea, Daruka Mahadevan, Michael Hammer, Christopher Morrison
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios
Bioimpedance System for Enhanced Positional Guidance
This technology is a biopsy system utilizing bioimpedance guidance to overcome limitations of current needles used in biopsy procedures. The research also provides bioimpedance based electrical control of bleeding complications. Background: According to statistics published by the World Health Organization, cancer has become one of the leading causes...
Published: 9/27/2022   |   Inventor(s): Michael Larson, Charles Hennemeyer
Category(s): Technology Classifications > Life Sciences
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