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CPS1 Markerless Deletion Mutant as a Method for Marker Deletion
This technology involves a novel system using a two-step process to eliminate a gene of interest by incorporating a “suicide gene” vector system. The construct created by this method results with no foreign sequences, making the strains markerless mutants. This means that one has the potential to make genetic strains with multiple mutations...
Published: 4/8/2024   |   Inventor(s): Maria Alejandra Mandel, Marc Orbach
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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools > Screening assays
Chemistry by Design
Title: Chemistry by DesignInvention: This invention is a custom database of worldwide approved pharmaceutical structures, including the United States FDA, that are available for use via a commercial app.Background: Any substance, or mixture of substances, that is planned to be an active ingredient for a drug product is classified as an active pharmaceutical...
Published: 3/12/2024   |   Inventor(s): Jon Njardarson
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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Software & Information Technology > Bioinformatics, Technology Classifications > Research Tools
New Deuterated Amino Acid Derivatives
Compositions and method of making involve use of alternative acids as reactants instead of carboxylic acids which produces deuterated amino acids, while carboxylic acids can only synthesize alkyl amino acids. Introducing deuterium to amino acids and derivatives improves biologically active compounds and therapeutics. Modification improves properties...
Published: 1/16/2024   |   Inventor(s): Wei Wang, Yue Dong
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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Life Sciences
Human Serum Albumin-Transgenic Mouse
A novel human albumin transgenic mouse model was developed which can be used to establish human protein biomarkers of exposure to hazardous xenobiotics for human risk assessment via animal studies. This can provide a unique in vivo tool for the assessment of risks of toxicity associated with human exposure to environmentally hazardous chemicals and...
Published: 1/10/2024   |   Inventor(s): Xinxin Ding
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Life Sciences
A Method of Treating Cardiomyopathy
This innovation is based on the finding that lack of Leiomodin-2 (Lmod2) is associated with cardiovascular issues, specifically enlarged heart or cardiomyopathy and it is better to have a truncated/mutated Lmod2 than zero or little Lmod2 present. A premature stop codon associated with Lmod2 causes truncation of Lmod2. This innovation is the use of antisense...
Published: 9/7/2023   |   Inventor(s): Christopher Pappas
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Category(s): Technology Classifications > Medical Devices, Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios
Enhancing Absorption of Dietary Compounds to Promote Health
This innovation is directed to oral co-administration of glucuronidase and polyphenols for reabsorption in the gut. Glucuronidase are enzymes that can be made or derived from any source such as bacteria, recombinant, species agnostic, and others. The inactive glucuronides are cleared from the body by secretion back into the gastrointestinal track where...
Published: 10/2/2023   |   Inventor(s): Janet Funk
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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Healthcare Portfolios
Practical Synthesis of C-1 Deuterated 3‑Formylindoles by Organo-photoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid
This innovation is the synthesis of a Carbon-based indole that can be used in the creation of anti-cancer drugs. Indoles are reagents that can also be used in oncological and renal disease treatment. The new method provides a simple protocol that creates differentiated indoles that have a broad functional tolerance. This uses a more cost-effective agent...
Published: 11/16/2023   |   Inventor(s): Wei Wang
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Materials, Technology Classifications > Materials > Chemicals
DNA E2E: End-to-End Programmable Microfluidic Platform (PMP) for DNA Data “Write-to-Store-to-Read” with Cold Storage of DNA Data in Synthetic Fossils and Metal-Organic Scaffolds using Supercritical Fluid (SCF) Processing
The inventors have combined an error-correcting information strategy for DNA with a supercritical fluid method for drying and storing DNA. The system features an apparatus suitable for end-to-end programmable DNA storage automation using a write-to-store-to-read data cycle via a programmable microfluidic platform (PMP). The system also features a method...
Published: 11/16/2023   |   Inventor(s): Frederic Zenhausern, Devasier Bennet, Tuan Vo-Dinh, Supreya Atta
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Materials > Biocompatible
Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...
Published: 7/6/2023   |   Inventor(s): Rui Chang
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Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 2/13/2024   |   Inventor(s): Hongmin Li, Zhong Li, Qing-yu Zhang
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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