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Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease.
Background:
Alzheimer’s disease (AD) is the most common form of dementia estimated to affect 36 million people worldwide and an estimated 115 million people by 2050. While doctors still don’t know the cause of AD, treatments...
Published: 5/17/2023
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Inventor(s): Rui Chang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 4/3/2023
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Inventor(s): Hongmin Li, Zhong Li, Qing-yu Zhang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Natural Compounds to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease.
Background:
Alzheimer’s disease (AD) is the most common form of dementia estimated to affect 36 million people worldwide and an estimated 115 million people by 2050. While doctors still don’t know the cause of AD, treatments...
Published: 6/3/2023
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Inventor(s): Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
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Methods and Compositions for Rapidly Replacing Cardiac Myosin Binding Protein-C in Sarcomeres
This technology is designed to be directed to a recombinant protein comprising myosin binding protein (MyBP-C) with an internal insertion. The internal insertion will comprise of at least a portion of a split-protein pair adjacent to a protease recognition site where the internal insertion is within or between C1 and C8 domains of the MyBP-C protein....
Published: 5/1/2023
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Inventor(s): Samantha Harris
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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Novel Main Protease Inhibitors as SARS-CoV-2 Antivirals
This technology encompasses the development of novel inhibitors for the main protease, or Mpro, of SARS-CoV-2. The main protease of SARS-CoV-2 is a validated drug target and could be key to the development of antiviral drugs against the virus. The inhibitors proposed in this technology are notable, as they are potent main protease inhibitors with high...
Published: 4/3/2023
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Inventor(s): Jun Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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KM Cells - A Metastatic Cell Line and Method of Producing
In this study, researchers at the University of Arizona investigated an early cancer invasion event using a unique in vivo model. Muscle invasion was tested by the ability of prostate cancer cells to colonize the inferior surface of the respiratory diaphragm of male NGS mice, invade into and through to the superior surface. They isolated and compared...
Published: 5/2/2023
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Inventor(s): Kendra Marr, Anne Cress
Keywords(s):
Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences
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Synapse Surgery Tools for Neural Circuit-Specific Synapse Ablation and Modification
Researchers at the University of Arizona have developed novel synapse manipulation tools, so called synapse surgery tools, using the endogenous synapse pruning system. Complement proteins tagging system for target synapses are effective in eliminating specific synapses relevant to neuronal functions and diseases. To accomplish this, the technology is...
Published: 4/24/2023
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Inventor(s): Deveroux Ferguson, Hee-Dae Kim
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools
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Vascular Plug
This technology is a small silicon item that is designed to fit in blood vessels to stop blood loss by plugging the vessels to allow for ligation of the vessel during surgical procedures. Prototypes of two durometers have been made. These plugs will come in slightly varied sizes to allow them to fit in any vessel.
Background:
The World Health Organization...
Published: 4/3/2023
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Inventor(s): Craig Weinkauf, Scott DeRigne
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Medical Devices
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Amphipathic Helical Glycopeptide Address Sequences for Enhanced Blood-Brain Barrier Transport of Neuroactive Peptides
University of Arizona researchers have successfully created a series of amphipathic helical glycopeptides with the ability to retain a membrane bound conformation promoting endocytosis as well as a water-soluble conformation facilitating exit from the membrane. This "biousian" property is intrinsic in allowing the molecule to traverse the...
Published: 4/3/2023
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Inventor(s): Robin Polt, Dhanasekaran Muthu
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Engineering & Physical Sciences
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Sex and APOE Genotype Precision Therapeutic Targets Discovery for Alzheimer’s Disease
This technology encompasses a formulation for patient subgroup-specific supplement for the treatment and therapy of Alzheimer's and other neurodegenerative diseases. These formulations can range in delivery method (food, drink, pill) and can be specific to patient subgroups.
Background:
Alzheimer’s disease is a progressive, neurodegenerative...
Published: 4/3/2023
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Inventor(s): Rui Chang, Roberta Brinton, Kuixi Zhu, Rima Kaddurah-Daouk
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
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