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A Method of Treating Cardiomyopathy
This innovation is based on the finding that lack of Leiomodin-2 (Lmod2) is associated with cardiovascular issues, specifically enlarged heart or cardiomyopathy and it is better to have a truncated/mutated Lmod2 than zero or little Lmod2 present. A premature stop codon associated with Lmod2 causes truncation of Lmod2. This innovation is the use of antisense...
Published: 9/7/2023
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Inventor(s): Christopher Pappas
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios
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A Method to Treat Neurodegenerative Diseases
This innovation is a method and composition for treating, preventing, or delaying the progression of neurodegenerative diseases using cell type-specific gene therapy. The therapy is delivered to human or veterinary subjects using an adeno-associated virus (AAV) vector that carries the peroxisome proliferator-activated receptor alpha (PPARA) gene. The...
Published: 9/8/2023
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Inventor(s): Fei Yin
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Neurology
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Enhancing Absorption of Dietary Compounds to Promote Health
This innovation is directed to oral co-administration of glucuronidase and polyphenols for reabsorption in the gut. Glucuronidase are enzymes that can be made or derived from any source such as bacteria, recombinant, species agnostic, and others. The inactive glucuronides are cleared from the body by secretion back into the gastrointestinal track where...
Published: 10/2/2023
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Inventor(s): Janet Funk
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Healthcare Portfolios
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Practical Synthesis of C-1 Deuterated 3‑Formylindoles by Organo-photoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid
This innovation is the synthesis of a Carbon-based indole that can be used in the creation of anti-cancer drugs. Indoles are reagents that can also be used in oncological and renal disease treatment. The new method provides a simple protocol that creates differentiated indoles that have a broad functional tolerance. This uses a more cost-effective agent...
Published: 7/27/2023
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Inventor(s): Wei Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Materials, Technology Classifications > Materials > Chemicals
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DNA E2E: End-to-End Programmable Microfluidic Platform (PMP) for DNA Data “Write-to-Store-to-Read” with Cold Storage of DNA Data in Synthetic Fossils and Metal-Organic Scaffolds using Supercritical Fluid (SCF) Processing
The inventors have combined an error-correcting information strategy for DNA with a supercritical fluid method for drying and storing DNA. The system features an apparatus suitable for end-to-end programmable DNA storage automation using a write-to-store-to-read data cycle via a programmable microfluidic platform (PMP). The system also features a method...
Published: 7/28/2023
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Inventor(s): Frederic Zenhausern, Devasier Bennet, Tuan Vo-Dinh, Supreya Atta
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Materials > Biocompatible
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Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...
Published: 7/6/2023
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Inventor(s): Rui Chang
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 7/28/2023
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Inventor(s): Hongmin Li, Zhong Li, Qing-yu Zhang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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Natural Compounds to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease.
Background:
Alzheimer’s disease (AD) is the most common form of dementia estimated to affect 36 million people worldwide and an estimated 115 million people by 2050. While doctors still don’t know the cause of AD, treatments...
Published: 6/3/2023
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Inventor(s): Rui Chang, Wassim Elyaman, Elizabeth Bradshaw, Patrick Ronaldson, Kuixi Zhu, Qianying He
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences
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Methods and Compositions for Rapidly Replacing Cardiac Myosin Binding Protein-C in Sarcomeres
This technology is designed to relate to myosin binding protein-C (MyBP-C), more particularly to methods and compositions for modifying MyBP-C in sarcomeres, e.g., protein engineering for studying MyBP-C in sarcomeres. It is an objective of the present invention to provide methods and compositions that allow for a single gene-edited mouse model that...
Published: 6/20/2023
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Inventor(s): Samantha Harris
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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Novel Main Protease Inhibitors as SARS-CoV-2 Antivirals
This technology encompasses the development of novel inhibitors for the main protease, or Mpro, of SARS-CoV-2. The main protease of SARS-CoV-2 is a validated drug target and could be key to the development of antiviral drugs against the virus. The inhibitors proposed in this technology are notable, as they are potent main protease inhibitors with high...
Published: 7/28/2023
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Inventor(s): Jun Wang
Keywords(s):
Category(s): Technology Classifications > Life Sciences
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