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Glycopeptide-Lipid Supramolecular Assembly
This invention provides an approach, including compositions and methods for delivering glycolipids to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin,...
Published: 3/15/2023
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Inventor(s): Robin Polt, Michael Heien
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology
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Myofilament Based Therapeutics for Cardiac Muscle Arrhythmias and Skeletal Muscle Tremors
This invention describes a novel therapeutic approach to treat cardiac muscle arrhythmias and skeletal muscle tremors.
Background:
Cardiac arrhythmias, such as those that cause atrial fibrillation or sudden cardiac death (SCD), are typically viewed as electrical/conduction abnormalities that drive uncoordinated heartbeats and their downstream health...
Published: 7/15/2022
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Inventor(s): Samantha Harris
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences
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A Novel Pan-T-Type Calcium Channel Modulator that alleviates Tonic, Neuropathic and Inflammatory Pain
This invention describes a non-opioid method to treat pain using a novel T-type calcium channel blocker.
Background:
Current treatments for many types of pain typically include opioid painkillers, which pose a significant risk of addiction and overdose in patients, creating a demand for a treatment with less risk and less side-effects. In neuropathic,...
Published: 2/13/2023
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Inventor(s): Rajesh Khanna, Jun Wang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules
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Decision Support Logic for Pharmacogenomics
This technology is a database of publicly available guidelines used in conjunction with medication recommendation algorithms. The technology is a clinical intervention support tool based upon Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. It leverages genomic information and accepted guidelines to deliver recommendations customized...
Published: 3/6/2023
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Inventor(s): A Departmental Work
Keywords(s):
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Software & Information Technology > Databases & Data Mining
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Therapeutic Nanoparticles for Renal Disease
University of Arizona researchers have developed a technology that uses biodegradable, polymeric nanoparticles to specifically deliver drugs to the kidney, thereby bypassing off target/organ effects. For example, drugs such as formoterol, a beta 2 adrenergic agonist, can be used to treat acute and chronic renal disease. Encapsulation of these drugs...
Published: 3/2/2023
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Inventor(s): Heidi Mansour, Rick Schnellmann, David Encinas Basurto, Ernest Vallorz
Keywords(s):
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Drug Delivery
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Allosteric NAMPT Activators for Metabolic and Neurological Disorders
This invention relates to a novel method of increasing the catalytic activity of the enzyme, nicotinamide phosphoribosyltransferase (NAMPT), which in turn increases the production of nicotinamide mononucleotide (NMN) that is converted to nicotinamide adenine dinucleotide (NAD). This process to increase supply of NAD in the body is accomplished using...
Published: 2/10/2023
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Inventor(s): Gregory Thatcher, Zhengnan Shen, Rui Xiong, Kiira Ratia, Yangfeng Li
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences
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Sugar-Based Low Molecular Weight Hydrogels from Alkyl Glycolipids
University of Arizona researchers have created sugar-based low molecular weight hydrogels that spontaneously self-assemble through weak, noncovalent intermolecular interactions. These gels are thixotropic, biocompatible, and biodegradable. Despite being held together through non-covalent interactions, these hydrogels exhibit greater mechanical strength...
Published: 11/15/2022
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Inventor(s): Jeanne Pemberton, Laurel Kegel, Yu-Cheng Wang
Keywords(s):
Category(s): Technology Classifications > Energy, Cleantech & Environmental > Remediation, Technology Classifications > Engineering & Physical Sciences > MEMS & Nanotechnology, Technology Classifications > Healthcare Portfolios > Dermatology, Technology Classifications > Healthcare Portfolios > Musculoskeletal Disorders, Orthopedics/Bone, Technology Classifications > Healthcare Portfolios > Regenerative Medicine / Tissue Engineering, Technology Classifications > Healthcare Portfolios > Wound Healing, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Materials > Biocompatible, Technology Classifications > Materials > Biomaterials, Technology Classifications > Materials > Medical Devices > Therapeutic, Technology Classifications > Materials > Nanomaterials
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Sphyingolipid-Derived Cancer Nanotherapeutics
This invention is an improvement to a commonly used drug delivery vehicle: liposomes. Liposomes, while useful for their improved pharmacokinetics, have not demonstrated significantly improved efficacy and patient survival. This may be in part due to the fact that generally only one drug can be loaded per liposome. However, this technology allows co-delivery...
Published: 8/18/2022
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Inventor(s): Jianqin Lu
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
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Formulations to Inhibit Hemotoxic Venoms
This invention uses the chemical element of Ruthenium compounded with other chemical substances and in conjunction with a carbon monoxide releasing molecule (CORM-2) as an anti-venom against four different venoms from the genera Bothrops, Calloselasma, Echis, and Oxyuranus.
Background:
According to the World Health Organization, it is estimated that...
Published: 1/10/2023
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Inventor(s): Vance Nielsen
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Emergency Medicine, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Medical Devices
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Design and Synthesis of Pro-Drugs for Selective, Oral Delivery to the Gastrointestinal Tract
This invention provides a method for oral administration and targeted delivery of pro-drugs bonded to a carbohydrate-based molecular scaffold to the gastrointestinal tract, where the pro-drug is released directly in the gastrointestinal (GI) tract by nitroreductase enzymes naturally present. This technology provides a means of delivery of GI therapies...
Published: 7/15/2022
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Inventor(s): Eugene Mash, Jr., Pawel Kiela
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
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