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Bioinspired Glycolipids as Fugitive Dust Suppression Agents
This technology involves the utilization of bioinspired glycolipids to reduce fugitive dust emissions.
Background:
Fugitive dust is defined by the EPA as dust which "arises from the mechanical disturbance of granular material exposed to air," and common sources of such materials include constructions sites, dirt roads, barren fields, mining...
Published: 2/27/2023
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Inventor(s): Minkyu Kim, David Hogan, Raina Maier
Keywords(s):
Category(s): Technology Classifications > Energy, Cleantech & Environmental, Technology Classifications > Energy, Cleantech & Environmental > Remediation > Soil, Technology Classifications > Life Sciences > Small Molecules
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DYRK/CLK PROTACS
This invention describes a set of novel molecules that target and degrade DYRK/CLK for several potential therapeutic purposes.
Background:
Proteolysis-targeting chimeric molecules (PROTACs) are small molecules used to decrease a gene’s protein expression by targeting the protein for ubiquitination and degradation after it is created. This mechanism...
Published: 2/17/2023
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Inventor(s): Christopher Hulme, Kevin Schofield, Walter Becker, Garrit Wilms
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Small Molecule Chaperones of CLN1 and CLN2
The inventors here have identified small molecules that target palmitoyl-protein thioesterase 1 (PPT1), tripeptidyl peptidase 1 (TPP1), enzymes that are deficient and less active in Batten disease or Neuronal Ceroid Lipofuscinosis. The CLN1 and CLN2 genes regulate the production of these enzymes, respectively.
Background:
Batten Disease, or Neural...
Published: 3/6/2023
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Inventor(s): May Khanna, Lipsa Jena
Keywords(s):
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Tetrazolium-Based Pro-Chelators as New Anticancer Agents
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types.
Background:
Iron is an essential...
Published: 1/19/2023
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Inventor(s): Elisa Tomat, Zoufeng Xu
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
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MC4R Selective Ligand for Obesity and Alzheimer’s Disease Prevention
This technology is a novel peptide that has been shown to be a potent MC4R selective antagonist. It is a potential therapeutic for cognitive loss and obesity.
Background:
The challenges of neurodegradation, Alzheimer’s disease, and obesity have been shown to have some similar molecular signatures that contribute to disease and have thus created...
Published: 9/26/2022
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Inventor(s): Minying Cai, Victor Hruby
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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Innovative Approaches to Optimize the Therapeutic Benefits of Autophagy Inhibition
This technology consists of novel, soluble compounds that are to be used to inhibit autophagy that can lead to pathogenesis of many different diseases and health conditions.
Background:
Autophagy is the process that regulates the degradation of overabundant malfunctioning cellular components. Autophagy is vital for maintaining cell renewal processes;...
Published: 2/10/2023
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Inventor(s): Jennifer Carew, Steffan Nawrocki, Wei Wang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
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A Novel Pan-T-Type Calcium Channel Modulator that alleviates Tonic, Neuropathic and Inflammatory Pain
This invention describes a non-opioid method to treat pain using a novel T-type calcium channel blocker.
Background:
Current treatments for many types of pain typically include opioid painkillers, which pose a significant risk of addiction and overdose in patients, creating a demand for a treatment with less risk and less side-effects. In neuropathic,...
Published: 2/13/2023
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Inventor(s): Rajesh Khanna, Jun Wang
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules
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Small Molecule Mixed Agonist/Antagonist for Opioid Receptors for Anti-Addiction and/or Pain Therapy
This invention provides compositions and method of pain treatment using a mixture of an opioid receptor agonist in combination with an adrenoreceptor modulator compound. The opioid receptor agonist may be a clinically-used drug, and the adrenoreceptor modulator compound is a novel small molecule. Proof-of-concept testing in animals has shown...
Published: 3/6/2023
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Inventor(s): Iman Daryaei, John Streicher, Abigail Schwarz
Keywords(s):
Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action
This invention describes an inhibitor of eIF4A, which is a validated cancer drug target. The inventors describe a novel mechanism by which this inhibitor works.
Background:
Oncogenic, or cancer-causing pathways have long been challenging drug targets, especially for complex cancers. One protein complex called eIF4F is key to select oncogenic pathways...
Published: 9/26/2022
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Inventor(s): Eli Chapman, Christopher Zerio
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology
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Photocatalytic Alpha Arylation of Carbonyls
This invention is a method for the synthesis of alpha arylation of inexpensive, unactivated carbonyl compounds with high yields at room temperature using any photocatalyst (PC) under visible light from blue to red.
Background:
Functionalization of the C-H bond has evolved as a fundamental principle that underpins both academic and industrial importance...
Published: 7/15/2022
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Inventor(s): Thomas Gianetti, Md Mubarak Hossain
Keywords(s):
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Processing, Technology Classifications > Life Sciences > Small Molecules
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