Search Results - technology+classifications+%3e+life+sciences+%3e+small+molecules

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Small Molecule Chaperones of CLN1 and CLN2
The inventors here have identified small molecules that target palmitoyl-protein thioesterase 1 (PPT1), tripeptidyl peptidase 1 (TPP1), enzymes that are deficient and less active in Batten disease or Neuronal Ceroid Lipofuscinosis. The CLN1 and CLN2 genes regulate the production of these enzymes, respectively. Background: Batten Disease, or Neural...
Published: 9/6/2022   |   Inventor(s): May Khanna, Jena Lipsa
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Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Tetrazolium-Based Pro-Chelators as New Anticancer Agents
This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Background: Iron is an essential...
Published: 8/11/2022   |   Inventor(s): Elisa Tomat, Zoufeng Xu
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
MC4R Selective Ligand for Obesity and Alzheimer’s Disease Prevention
This technology is a novel peptide that has been shown to be a potent MC4R selective antagonist. It is a potential therapeutic for cognitive loss and obesity. Background: The challenges of neurodegradation, Alzheimer’s disease, and obesity have been shown to have some similar molecular signatures that contribute to disease and have thus created...
Published: 7/27/2022   |   Inventor(s): Minying Cai, Victor Hruby
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
Innovative Approaches to Optimize the Therapeutic Benefits of Autophagy Inhibition
This technology consists of novel, soluble compounds that are to be used to inhibit autophagy that can lead to pathogenesis of many different diseases and health conditions. Background: Autophagy is the process that regulates the degradation of overabundant malfunctioning cellular components. Autophagy is vital for maintaining cell renewal processes;...
Published: 2/22/2022   |   Inventor(s): Jennifer Carew, Steffan Nawrocki, Wei Wang
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Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Small Molecules
A Novel Pan-T-Type Calcium Channel Modulator that alleviates Tonic, Neuropathic and Inflammatory Pain
This invention describes a non-opioid method to treat pain using a novel T-type calcium channel blocker. Background: Current treatments for many types of pain typically include opioid painkillers, which pose a significant risk of addiction and overdose in patients, creating a demand for a treatment with less risk and less side-effects. In neuropathic,...
Published: 2/10/2022   |   Inventor(s): Rajesh Khanna, Jun Wang
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Category(s): Technology Classifications, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules
Small Molecule Mixed Agonist/Antagonist for Opioid Receptors for Anti-Addiction and/or Pain Therapy
This invention provides compositions and method of pain treatment using a mixture of an opioid receptor agonist in combination with an adrenoreceptor modulator compound. The opioid receptor agonist may be a clinically-used drug, and the adrenoreceptor modulator compound is a novel small molecule. ­Proof-of-concept testing in animals has shown...
Published: 1/4/2022   |   Inventor(s): Iman Daryaei, John Streicher, Abigail Schwarz
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action
This invention describes an inhibitor of eIF4A, which is a validated cancer drug target. The inventors describe a novel mechanism by which this inhibitor works. Background: Oncogenic, or cancer-causing pathways have long been challenging drug targets, especially for complex cancers. One protein complex called eIF4F is key to select oncogenic pathways...
Published: 12/6/2021   |   Inventor(s): Eli Chapman, Christopher Zerio
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Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology
Photocatalytic Alpha Arylation of Carbonyls
This invention is a method for the synthesis of alpha arylation of inexpensive, unactivated carbonyl compounds with high yields at room temperature using any photocatalyst (PC) under visible light from blue to red. Background: Functionalization of the C-H bond has evolved as a fundamental principle that underpins both academic and industrial importance...
Published: 11/19/2021   |   Inventor(s): Thomas Gianetti, Md Mubarak Hossain
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Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Materials > Processing, Technology Classifications > Life Sciences > Small Molecules
Novel Antibiotic Drug Combination Including an Anti-Inflammatory Metabolite
This technology involves a combination of a metabolite, 3-hydroxyanthanilic acid (3HAA) with a compound that alters cellular iron homeostasis (e.g. an iron chelator or an iron supplement) that produces synergistic antibiotic interaction. 3HAA sensitizes bacteria to changes in iron availability (both increasing iron media content through supplementation...
Published: 11/12/2021   |   Inventor(s): George Sutphin, Luis Espejo
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Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Selective Melanotropin 4 Ligands for Neurodegenerative Diseases
This technology is the development of ligands that selectively bind to the Melanocortin 3 Receptor (MC3R) and Melanocortin 4 Receptor (MC4R) and modulate receptor activity for neurodegenerative diseases. The melanocortin receptor ligand is bound to an MC3R and/or MC4R selective moiety, which allows the complex to cross the blood brain barrier. The ligand-moiety...
Published: 9/2/2021   |   Inventor(s): Minying Cai, Victor Hruby
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
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