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Organoid Models of Pituitary Adenomas
This technology is a patient derived organoid of a pituitary adenoma for the purpose of identifying treatment for Cushing’s Disease (CD). The lack of specificity of current standard of care treatments with low efficacy and tolerability makes CD a medical therapeutic challenge. One major limitation to developing new medical therapies is the lack...
Published: 9/7/2022   |   Inventor(s): Yana Zavros, Andrew Little
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Category(s): Technology Classifications > Research Tools, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity
A Homemade Device for Simultaneous Measurement of Pulmonary Ventilation and Metabolic Rate in Neonatal Rodents
University of Arizona researchers have developed a way of measuring and studying neonatal rodents' breathing activity and metabolic rate simultaneously using this homemade dual chamber technology. This inexpensive and simple tool is also useful for comparing the ventilatory and metabolic responses to various stressors, including hypoxia, acute inflammatory...
Published: 4/19/2022   |   Inventor(s): Ralph Fregosi, Christina Hoyer-Kimura
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Category(s): Technology Classifications > Research Tools
HIF-1alpha Phospho-T455 Antibody
­This invention relates to a polyclonal antibody against a novel phosphorylation site that is known to be correlated with increased tumor growth. Specifically, the antibody targets a phosphorylation site on HIF-1α which is controlled by PIM kinases. This invention can be used not only as a therapeutic against cancer but also potentially as...
Published: 4/19/2022   |   Inventor(s): Noel Warfel
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Category(s): Technology Classifications > Research Tools, Technology Classifications, Technology Classifications > Healthcare Portfolios > Oncology
Variance of Fixed Joint Space Width and Nomogram to Predict Knee Replacement using Measures from Fixed Flexion Knee X-rays
The cartilage underneath our knees keeps the bones in our legs from rubbing together. Unfortunately for many, this cartilage wears abnormally thin over time and causes physiological problems. If, however, this can be detected before it becomes a serious issue for the patient, then the patient can receive treatments before the painful problem can be...
Published: 3/2/2022   |   Inventor(s): Chian Kwoh, Erin Ashbeck, Edward Bedrick
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Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Musculoskeletal Disorders, Orthopedics/Bone, Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Simulators and Modeling Tools
Variable-Pressure Head-Out Plethysmography Chamber with Data Acquisition and Analysis Software
Animal studies have always been a large part of scientific and medical discoveries both for the animals being studied and for eventual human application. Plethysmography, studying the changes in the volume of a body or organ, is a critical part of those studies. Here specifically is the study of respiration endpoints in mice and rats given different...
Published: 1/19/2022   |   Inventor(s): Kyle Kentch, Stephanie Bruggink, Benjamin Renquist
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Category(s): Technology Classifications > Research Tools, Technology Classifications > Software & Information Technology
Disposable Partial Vertebrate Animal Cage Divider
This technology is a unique animal welfare product that mimics burrow-like structures, increases engagement, and reduces aggression. The innovation was designed at a University of Arizona laboratory for group-housed mice. Background: Current caging technologies remain expensive and inadequate to provide vertebrate lab animals with separation from...
Published: 1/18/2022   |   Inventor(s): Bret Tallent, Jonathan Lifshitz
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Category(s): Technology Classifications > Research Tools, Technology Classifications > Creative Works, Technology Classifications > Veterinary Medicine
Tunable Fluorescent Indolizine Tetracycles
This technology is tunable fluorescent probes that are able to span the colors of the rainbow. The main benefit of this technology is that it can be prepared in only one or two steps; as opposed to the five to seven steps it would normally take. Not only is this technology quicker, but the cost of goods is also more reasonable and compares very favorably...
Published: 1/18/2022   |   Inventor(s): Christopher Hulme, Nathan Bedard
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Category(s): Technology Classifications, Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Reagents
Apparatus for Active Tissue Scaffold Stretching in Cell Culture Conditions
This invention is a means to apply controlled dynamic forces on a macroscale tissue scaffold along a period of cell culture conditions that can range from minutes to weeks. This apparatus uses a mechanically compliant substrate, which can be made from various materials, that supports the attached tissue scaffold. The apparatus also contains a holder...
Published: 1/18/2022   |   Inventor(s): Ashlee Harris, Jerome Lacombe, Baiju Thomas, Matthew Barrett, Frederic Zenhausern, Alan Nordquist
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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Simulators and Modeling Tools
9A7 Monoclonal Ab
This invention is an IgG2b monoclonal antibody that targets vitamin D receptor (VDR) and is made and derived from Lewis rats with partially purified chicken intestinal vitamin D receptor. Background: 1,25-dihydroxyvitamin D3 receptor (VDR) is implicated in a range of inflammatory, dermatological, osteoporosis, cancers and autoimmune conditions. The...
Published: 9/30/2021   |   Inventor(s): Carol Haussler, Mark Haussler, J. Wesley Pike, Samuel Marion
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Category(s): Technology Classifications, Technology Classifications > Research Tools
Algorithm and Software for a Quantum Molecular Non-Born-Oppenheimer Model to Predict Molecular Interactions with a Magnetic Field
This invention is an algorithm developed and implemented for a new non-Born-Oppenheimer method for atomic quantum-mechanical calculations to predict fine structure corresponding to atomic transitions for atoms or molecules in a strong magnetic field. This algorithm was programmed and tested in calculations of hydrogen deuteride (HD) in a stationary...
Published: 10/23/2020   |   Inventor(s): Ludwik Adamowicz, Monika Stanke
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Category(s): Technology Classifications > Energy, Cleantech & Environmental > Nuclear, Technology Classifications > Engineering & Physical Sciences > Communications & Networking, Technology Classifications > Engineering & Physical Sciences > Electronics, Technology Classifications > Imaging & Optics > Sensors and Detection, Technology Classifications > Research Tools, Technology Classifications > Software & Information Technology
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