Invention:
This technology is an improved method for maximizing the solubility of the flavonoid rutin to effectively protect bees against the harmful effects of fipronil and deltamethrin, two types of commonly used pesticides. This technology serves as a non-toxic alternative to the current method of rutin dissolution, and has no physiological or cognitive side effects on the honeybees themselves. Notably, this method offers a promising approach for enhancing the bioavailability of rutin, potentially amplifying its therapeutic and protective benefits.
Background:
Flavonoids are nutraceutical molecules derived from plants and have been studied for more than a century in diverse contexts, from cell culture to clinical trials. However, constraints in flavonoid solubility in water have been a challenge for research and administration. As the main alternative, Dimethyl Sulfoxide (DMSO) is used to dissolve flavonoids as well as other polar and nonpolar molecules. DMSO has been widely recognized for its presumed non-toxicity and is approved for tests in toxicology. However, recent evidence suggests that DMSO may be toxic even at low concentrations, questioning its reliability in bioassays. This evidence purports the need for an alternative for flavonoid dissolution.
Applications:
- Honeybee research
- Flavonoid dissolution
- Agriculture research/practices
- General biomedical research
Advantages:
- Non-toxic alternative to traditional methods
- Provides cognitive protection for honeybees
