Annulation to Produce Heterocyclic Compounds

Case ID:

This invention describes a novel way to generate heterocyclic compounds via a 3+2 annulation. This method requires no expensive reagents, and can be done in a chiral manner in some instances.

Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. The invention possess no such drawbacks and is able to create heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds.

Can be used to synthesize a variety of drugs conducive to

  • Anti HIV compounds
  • Anti hypertensive compounds
  • Analgesics
  • Cancer therapeutics


  • Cost effective relative to the existing options
  • One pot reaction, allowing for faster turnaround time
  • Can generate chiral compounds
Patent Information:
Contact For More Information:
Laura Silva
Sr. Licensing Manager, COS
The University of Arizona
Lead Inventor(s):
Jon Njardarson
Isaac Chogii