Coronavirus Therapeutics

Case ID:

This technology introduces a potent covalent enzyme inhibitor designed specifically for targeting the cysteine protease, PLpro, a key player in the replication process of SARS coronaviruses like SARS-CoV-2 and MERS. Unlike traditional small molecule inhibitors, this inhibitor offers unparalleled efficacy and specificity, making it a promising candidate for combating viral infections. By precisely targeting PLpro, the virus's ability to replicate and evade the host immune system is disrupted, ultimately inhibiting its spread within the body. With the global need for effective solutions against emerging infectious diseases, this approach and promising results make it a valuable asset in the ongoing battle to protect public health worldwide.

The technology addresses the challenge of effectively targeting the cysteine protease, PLpro, a critical enzyme for the replication of SARS coronaviruses such as SARS-CoV-2 and MERS. Current solutions for inhibiting PLpro, primarily small molecule inhibitors, face limitations due to the enzyme's complex structure and lack of suitable binding sites. As a result, there is a pressing need for more effective and specific inhibitors to combat these viruses and prevent their spread. Unlike traditional inhibitors, this technology offers enhanced efficacy and specificity, enabling precise disruption of viral replication processes while minimizing off-target effects. By addressing the shortcomings of current technologies, this innovative inhibitor represents a significant advancement in the fight against coronaviruses and other viral infections.


  • Antiviral therapy
  • Pharmaceutical research and development


  • Enhanced efficacy in targeting cysteine protease PLpro
  • Improved specificity, minimizing off-target effects
  • Potential for broader applications in combating various coronaviruses
  • Contribution to the development of novel antiviral therapies
  • Accelerated progress in pharmaceutical research and drug discovery efforts
Patent Information:
Contact For More Information:
Garrett Edmunds
Licensing Manager, UAHS-TLA
The University of Arizona
Lead Inventor(s):
Rui Xiong
Gregory Thatcher
Divakar Indukuri
Kiira Ratia
Li jun Rong